Περίληψη:
In a large case-control study on breast cancer risk and serum hormone
concentrations, nested within the European Prospective Investigation
into Cancer and Nutrition (EPIC) cohort, we examined to what extent the
relationship of excess body weight with breast cancer risk may be
explained by changes in sex steroids. Height, weight, waist and hip
circumferences, and serum measurements of testosterone [T],
androstenedione [Delta(4)], dehydroepiandrosterone sulphate [DHEAS],
estradiol [E-2], estrone [E-1] and sex-hormone binding globulin
[SHBG] were available for 613 breast cancer cases, and 1,139 matched
controls, who were all menopausal at the time of blood donation. Free T
[fT] and free E-2 [fE(2)] were calculated using mass action
equations. Breast cancer risk was related to body mass index (BMI) (RR =
1.11 [0.99-1.25], per 5 kg/m(2) increase in BMI), and waist (RR = 1.12
[1.02-1.24], per 10 cm increase) and hip circumferences (RR = 1.14
[1.02-1.27], per 10 cm increase). The increase in breast cancer risk
associated with adiposity was substantially reduced after adjustment for
any estrogens, especially for fE(2) (from 1.11 [0.99-1.25] to 0.99
[0.87-1.12], from 1.12 [1.02-1.24] to 1.02 [0.92-1.14] and from
1.14 [1.02-1.27] to 1.05 [0.93-1.18] for BMI, waist and hip
circumferences, respectively). A modest attenuation in excess risk was
observed after adjustment for fT, but the remaining androgens had little
effect on the association of body adiposity with breast cancer. Our data
indicate that the relationship of adiposity with breast cancer in
postmenopausal women could be partially explained by the increases in
endogenous estrogens, and by a decrease in levels of SHBG. (c) 2005
Wiley-Liss, Inc.
Συγγραφείς:
Rinaldi, S
Key, TJ
Peeters, PHM
Lahmann, PH
Lukanova, A
and Dossus, L
Biessy, C
Vineis, P
Sacerdote, C
Berrino,
F
Panico, S
Tumino, R
Palli, D
Nagel, G
Linseisen, J
and Boeing, H
Roddam, A
Bingham, S
Khaw, KT
Chloptios, J
and Trichopoulou, A
Trichopoulos, D
Tehard, B and
Clavel-Chapelon, F
Gonzalez, CA
Larranaga, N
Barricarte, A
and Quiros, JR
Chirlaque, MD
Martinez, C
Monninkhof, E and
Grobbee, DE
Bueno-De-Mesquita, HB
Ferrari, P
Slimani, N and
Riboli, E
Kaaks, R
