Τίτλος:
Role of soluble triggering receptor expressed on myelold cells in
inflammatory bowel disease
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
AIM: To investigate the probable role of soluble triggering receptor
expressed on myeloid cells-1 (sTREM-1) in the pathogenesis of
inflammatory bowel disease (IBD).
METHODS: Fifty-eight patients were enrolled; nineteen healthy volunteers
served as controls; 8 patients were diagnosed with Crohn’s disease, and
31 with ulcerative colitis. Clinical and endoscopic activity indexes of
patients with Crohn’s disease and ulcerative colitis respectively were
estimated. Upon admission blood was sampled; sTREM-1 and TNF alpha were
measured by an immunoassay and malondialdehyde (MDA) by the
thiobarbitourate assay, after passage through an HPLC system.
RESULTS: Median SE of TNFa of controls, patients with Crohn’s disease
and patients with ulcerative colitis were 6.02 +/- 3.94, 7.98 +/- 5.08
(P = NS vs controls), and 8.45 +/- 4.15 ng/L (P = 0.018 vs controls)
respectively. Respective values of sTREM-1 were 53.31 +/- 32.93, 735.10
+/- 197.17 (P = 0.008 vs controls) and 435.82 +/- 279.71 ng/L (P = 0.049
vs controls). sTREM-1 was positively correlated with Crohn’s disease
activity index and clinical and endoscopic activity indexes of
ulcerative colitis (P = 0.002, 0.001 and 0.009, respectively). sTREM-1
of patients with ulcerative colitis was positively correlated with TNF
alpha (P = 0.001).
CONCLUSION: sTREM-1 seems to behave as a novel mediator in IBD in
correlation with the degree of the :inflammatory reaction of the
intestinal mucosa. 2006 The WIG Press. All rights reserved.
Συγγραφείς:
Tzivras, Michalis
Koussoulas, Vassilios
Giamarellos-Bourboulis,
Evangelos J.
Tzivras, Dimitrios
Tsaganos, Thomas
Koutoukas,
Pantelis
Giamarellou, Helen
Archimandritis, Athanasios
Περιοδικό:
World Journal of Gastroenterology
Λέξεις-κλειδιά:
STREM-1; pro-inflammatory cytokines; malondialdehyde; inflammatory bowel
disease
DOI:
10.3748/wjg.v12.i21.3416
