Περίληψη:
The incidence of FLT3 mutations (internal tandem duplication and Asp835)
was investigated in bone marrow samples from 97 patients with
myelodysplastic syndrome [(MDS); excluding cases with refractory
anaemia with excess blasts in transformation] at the time of diagnosis
and several time points thereafter. Three patients had FLT3 mutations at
presentation. Forty-two patients progressed to acute myeloid leukaemia
(AML), including the three patients with FLT3 mutations at MDS
diagnosis. Three additional patients acquired FLT3 mutations and
progressed to AML in 1 month. FLT3 mutations seem to be a critical
additional genetic event that transforms a minority of MDS patients to
AML.
Συγγραφείς:
Georgiou, Georgios
Karali, Vasiliki
Zouvelou, Christina and
Kyriakou, Elias
Dimou, Maria
Chrisochoou, Stamatis
Greka,
Paraskevi
Dufexis, Dimitrios
Vervesou, Elisavet
Dimitriadou,
Evaggelia
Efthymiou, Anna
Petrikkos, Loizos
Dima, Katerina
and Lilakos, Konstantinos
Panayiotidis, Panayiotis
