Περίληψη:
Objectives: We examined the association between obesity and early-onset cryptogenic ischemic stroke (CIS) and whether fat distribution or sex altered this association. Materials and Methods: This prospective, multi-center, case-control study included 345 patients, aged 18-49 years, with first-ever, acute CIS. The control group included 345 age- and sex-matched stroke-free individuals. We measured height, weight, waist circumference, and hip circumference. Obesity metrics analyzed included body mass index (BMI), waist-to-hip ratio (WHR), waist-to-stature ratio (WSR), and a body shape index (ABSI). Models were adjusted for age, level of education, vascular risk factors, and migraine with aura. Results: After adjusting for demographics, vascular risk factors, and migraine with aura, the highest tertile of WHR was associated with CIS (OR for highest versus lowest WHR tertile 2.81, 95%CI 1.43-5.51; P=0.003). In sex-specific analyses, WHR tertiles were not associated with CIS. However, using WHO WHR cutoff values (>0.85 for women, >0.90 for men), abdominally obese women were at increased risk of CIS (OR 2.09, 95%CI 1.02-4.27; P=0.045). After adjusting for confounders, WC, BMI, WSR, or ABSI were not associated with CIS. Conclusions: Abdominal obesity measured with WHR was an independent risk factor for CIS in young adults after rigorous adjustment for concomitant risk factors. © 2022 The Author(s)
Συγγραφείς:
Jaakonmäki, N.
Zedde, M.
Sarkanen, T.
Martinez-Majander, N.
Tuohinen, S.
Sinisalo, J.
Ryödi, E.
Autere, J.
Hedman, M.
Junttola, U.
Huhtakangas, J.K.
Grimaldi, T.
Pascarella, R.
Nordanstig, A.
Bech-Hanssen, O.
Holbe, C.
Busch, R.
Fromm, A.
Ylikotila, P.
Turgut, E.E.
Amorim, I.
Ryliskiene, K.
Tulkki, L.
Pascasio, L.A.
Licenik, R.
Ferdinand, P.
Tsivgoulis, G.
Jatužis, D.
Kõrv, L.
Kõrv, J.
Pezzini, A.
Fonseca, A.C.
Yesilot, N.
Roine, R.O.
Waje-Andreassen, U.
von Sarnowski, B.
Redfors, P.
Huhtakangas, J.
Numminen, H.
Jäkälä, P.
Putaala, J.
the SECRETO Study Group
