Τίτλος:
Balanced control of both hyper and hypo-inflammatory phases as a new treatment paradigm in sepsis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The immune response of the host against invading pathogens is clinically manifested as sepsis. Sepsis is a complicated process characterized by distinct phases that usually occur in a sequential manner. The initial hyper-inflammation helps in elimination of the pathogen, but potentially may lead to excessive tissue injury. Hypo-inflammation helps in restoring immune homeostasis, but may lead to significant immune suppression and death from secondary infections if not appropriately controlled. Immune-modulating intervention in sepsis should be based on a balanced control of both the hyper and the hypo-inflammatory phase. © 2016. Journal of Thoracic Disease.
Συγγραφείς:
Tsirigotis, P.
Chondropoulos, S.
Gkirkas, K.
Meletiadis, J.
Dimopoulou, I.
Περιοδικό:
Journal of thoracic disease
Εκδότης:
Pioneer Bioscience Publishing
Λέξεις-κλειδιά:
Janus kinase; ruxolitinib; STAT protein, Article; clinical effectiveness; cytokine production; disease activity; disease association; drug efficacy; drug response; homeostasis; human; hyperinflammation; hypoinflammation; immune response; immunomodulation; immunosuppressive treatment; inflammation; molecular pathology; nonhuman; outcome assessment; patient monitoring; sepsis; treatment failure
DOI:
10.21037/jtd.2016.03.47
