Τίτλος:
Downregulation of the neonatal Fc receptor expression in nonsmall cell lung cancer tissue is associated with a poor prognosis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Lung cancer is the leading cause of cancer-related death worldwide. Although the recommended tumor, node and metastasis (TNM) classification and stage determination are important to select therapeutic options for patients with non-small cell lung carcinoma (NSCLC), additional molecular markers are required to indicate the prognosis, in particular within a specific stage, and help with the management of patients. Because neonatal Fc receptor (FcRn) has recently been involved in colon cancer immunosurveillance, we measured its expression in non-cancerous and NSCLC lung tissues and evaluated its prognostic value in overall survival for patient with NSCLC. FcRn expression was determined at both mRNA and protein levels on cancerous and adjacent non-cancerous tissues from 80 NSCLC patients. In NSCLC, FcRn was mainly found in resident and tumor infiltrating immune cells. The corresponding mRNA and protein were significantly less abundant in lung tumor than non-cancerous tissue. Moreover, analysis of our cohort and datasets from the public data bases show that FCGRT mRNA down-regulation is a robust and independent, unfavorable predictive factor of NSCLC patient survival. We conclude that FCGRT mRNA expression may be a useful additional marker for immunoscoring, reflecting tumor immune system, and help in the decision-making process for NSCLC patients.
Συγγραφείς:
Dalloneau, E.
Baroukh, N.
Mavridis, K.
Maillet, A.
Gueugnon, F.
Courty, Y.
Petit, A.
Kryza, T.
Del Rio, M.
Guyetant, S.
Cadena Castaneda, D.C.
Dhommée, C.
Arnoult, C.
Scorilas, A.
Gouilleux-Gruart, V.
Heuzé-Vourc'h, N.
Περιοδικό:
OncoTargets and therapy
Εκδότης:
Impact Journals, LLC
Λέξεις-κλειδιά:
Fc receptor; messenger RNA; Fc receptor; Fc receptor, neonatal; HLA antigen class 1; messenger RNA; tumor marker, Article; cancer prognosis; cancer staging; cohort analysis; colon cancer; controlled study; disease association; down regulation; FCGRT gene; female; gene expression; human; human tissue; immunosurveillance; major clinical study; male; non small cell lung cancer; overall survival; protein expression; tumor associated leukocyte; tumor immunity; adult; aged; chemistry; gene expression regulation; genetics; immunology; lung; lung tumor; middle aged; mortality; non small cell lung cancer; prognosis; proportional hazards model; very elderly, Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Histocompatibility Antigens Class I; Humans; Lung; Lung Neoplasms; Male; Middle Aged; Prognosis; Proportional Hazards Models; Receptors, Fc; RNA, Messenger
DOI:
10.18632/oncotarget.10074
