Περίληψη:
Background: Lipoprotein-associated Phospholipase A2 (Lp-PLA2), can exert proinflammatory as well as proatherogenic properties on the vascular wall. The current study sought to evaluate the influence of high Lp-PLA2 levels on indices of arterial wall properties in patients with stable coronary artery disease (CAD). Methods: Three hundred seventy-four consecutive patients with stable CAD (mean age 61 ± 11 years, 89% males) were enrolled in this single-center cross-sectional study. Flow-mediated dilation (FMD) was used to assess endothelial function and augmentation index (AIx) of the central aortic pressure was used to assess reflected waves. ELISA was used to determine Lp-PLA2 serum levels. Results: After dividing the participants in 3 equal groups based on the tertiles of circulating Lp-PLA2 values, no significant differences were demonstrated between those in the 3rd tertile with Lp-PLA2 values > 138 μg/L, in the 2nd tertile with Lp-PLA2 values between 101 and 138 μg/L and in the 1st tertile (Lp-PLA2 values < 101 μg/L) regarding age, male gender, smoking habits, family history of CAD or history of a previous myocardial infarction, diabetes mellitus, arterial hypertension, hyperlipidemia, duration of CAD and treatment with relevant medication. Importantly, subjects with Lp-PLA2 values in the highest tertile, had significantly reduced FMD values compared to the middle and lower tertile (4.43 ± 2.37% vs. 4.61 ± 1.97% vs. 5.20 ± 2.52% respectively, P = 0.03). Patients in the highest tertile of Lp-PLA2 values had significantly higher AIx values (24.65 ± 8.69% vs. 23.33 ± 9.65%, P = 0.03), in comparison to the lowest tertile, with Lp-PLA2 values < 101 μg/L. A linear regression analysis showed that Lp-PLA2 values > 138 μg/L negatively correlated to FMD [b = − 0.45 (95% CI: − 0.79 – -0.11), P = 0.01] and AIx values [b = 1.81 (95% CI: 0.57–3.05), P < 0.001] independently of cofounders like gender, age, diabetes mellitus, arterial hypertension, dyslipidemia, smoking habits, family history of CAD, history of previous myocardial infarction, serum glucose, circulating lipid levels, duration of CAD, antihypertensive medication, antidiabetic drugs, statin therapy and treatment with β-blockers. Conclusions: Elevated Lp-PLA2 levels relate to endothelial dysfunction and arterial stiffness in patients with stable CAD independently from classical risk factors for CAD, statin use, antihypertensive treatment, and duration of the disease. © 2021, The Author(s).
Συγγραφείς:
Mourouzis, K.
Siasos, G.
Oikonomou, E.
Zaromitidou, M.
Tsigkou, V.
Antonopoulos, A.
Bletsa, E.
Stampouloglou, P.
Vlasis, K.
Vavuranakis, M.
Tousoulis, D.
Λέξεις-κλειδιά:
angiotensin receptor antagonist; beta adrenergic receptor blocking agent; dipeptidyl carboxypeptidase inhibitor; lipoprotein; phospholipase A2; 1 alkyl 2 acetylglycerophosphocholine esterase, adult; age distribution; aortic pressure; arterial stiffness; Article; augmentation index; cardiovascular parameters; controlled study; coronary angiography; coronary artery disease; cross-sectional study; diabetes mellitus; disease duration; endothelial dysfunction; enzyme linked immunosorbent assay; family history; female; flow-mediated dilation test; heart infarction; human; hyperlipidemia; hypertension; major clinical study; male; protein function; risk assessment; risk factor; sex difference; smoking habit; arterial stiffness; coronary artery disease; metabolism; middle aged; pathophysiology; physiology; statistical model; vascular endothelium, 1-Alkyl-2-acetylglycerophosphocholine Esterase; Coronary Artery Disease; Endothelium, Vascular; Female; Humans; Linear Models; Male; Middle Aged; Vascular Stiffness
