Τίτλος:
Profiling immune-evasion pathways in a Merkel cell carcinoma (MCC)
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
This case report presents the results of a pilot immuno-phenotypic evaluation of a MCPyV large T-antigen positive Merkel cell carcinoma (MCC). The overall results show a profound immunological imbalance in the MCC microenvironment. An evident prevalence of T-cell infiltration was accompanied by extensive expression of regulatory T-cell markers, like CD25 and FOXP3. An active PDL1/PD1 immunosuppressive pathway is supported by the immunohistochemical findings. The macrophage inhibitory CD47/SIRPα pathway is up-regulated, although macrophage blockage seems to be mediated by a lymphocyte subpopulation expressing CD47, and not by MCC cells that were negative. The most striking finding was the extensive loss of HLA-class-I, and related β2-microglobulin and TAP-1 molecules expression, which predicts for impaired dendritic activation and cancer cell recognition by cytotoxic T-cells. A subset of infiltrating lymphocytes also overexpresses arginase and ectonucleotidases that further contributes to an immunosuppressive arginine-depleted and adenosine-rich microenvironment. © 2021 The Author(s)
Συγγραφείς:
Koukourakis, I.M.
Arelaki, S.
Tsihrintzis, K.V.
Tsaroucha, A.
Περιοδικό:
Human Pathology: Case Reports
Εκδότης:
HANLEY & BELFUS-ELSEVIER INC
Λέξεις-κλειδιά:
B7 antigen; CAM5.2; CD4 antigen; CD47 antigen; CD56 antigen; CD68 antigen; CD8 antigen; CD86 antigen; chromogranin; cytokeratin 20; cytotoxic T lymphocyte antigen 4; FLI1; PGP9.5; programmed death 1 ligand 1; programmed death 1 receptor; synaptophysin; T lymphocyte receptor; transcription factor FOXP3; unclassified drug, adult; Article; case report; CD25+ T lymphocyte; clinical article; cytotoxic T lymphocyte; gluteal mass; gluteus muscle; human; human tissue; immunohistochemistry; male; merkel cell carcinoma; Merkel cell polyomavirus; middle aged; tumor associated leukocyte; tumor escape; tumor-associated macrophage
DOI:
10.1016/j.hpr.2021.300561
