Τίτλος:
Eosinophilic Esophagitis and Achalasia: Two Distinct Nosologic Entities or a Possible Etiopathogenic Association?
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Despite the fact that researchers have made significant progress in elucidating the pathophysiology of esophageal diseases, the understanding of esophageal motility alterations in patients with eosinophilic esophagitis (EoE) is in its infancy and current published medical literature remains rather scarce on this topic. A growing body of scientific data regarding associations between esophageal motor disorders, such as achalasia and EoE, exists nowadays. Summary: It seems that the association of EoE and achalasia does not constitute a cause and effect relationship, as it is not clear whether esophageal motility abnormalities are the result of EoE or vice versa. As such, there is no universally accepted treatment algorithm for patients presenting with both of these entities. Key Messages: The aim of this article is to review the existing data on achalasia-like motility disorders in patients with EoE, highlighting a possible association between these 2 esophageal disorders. Moreover, we seek to describe the clinical presentation in such cases, diagnostic modalities to be used, and current treatment strategies in patients suspected to suffer from both disorders. © 2021
Συγγραφείς:
Schizas, D.
Syllaios, A.
Vailas, M.
Sotiropoulou, M.
Triantafyllou, T.
Tsapralis, D.
Papanikolaou, I.S.
Theodorou, D.
Περιοδικό:
Digestive Diseases
Λέξεις-κλειδιά:
botulinum toxin; budesonide; calpain; chemokine; corticosteroid; desmoglein; filaggrin; fluticasone; interleukin 13; interleukin 4; interleukin 5; interleukin 6; interleukin 8; leukotriene D4; omeprazole; prednisolone; prostaglandin F2; proton pump inhibitor; thromboxane B2; transforming growth factor beta; tryptase; vasculotropin, algorithm; biopsy; clinical study; diagnostic accuracy; diagnostic test accuracy study (topic); dysphagia; endoscopy; eosinophil; eosinophilic esophagitis; eosinophilic gastroenteritis; esophagogastroduodenoscopy; esophagoscopy; esophagus achalasia; esophagus motility; esophagus mucosa; esophagus muscle; female; human; human tissue; immunohistochemistry; inflammation; lamina propria; male; manometry; muscle biopsy; muscle relaxation; myotomy; quality of life; questionnaire; Review; steroid therapy; T lymphocyte; upregulation; complication; eosinophilic esophagitis; esophagus achalasia; esophagus function disorder, Algorithms; Eosinophilic Esophagitis; Esophageal Achalasia; Esophageal Motility Disorders; Humans
