Περίληψη:
Introduction: Epidemiological data from patients with COVID-19 has been recently published in several countries. Nationwide data of hospitalized patients with COVID-19 in Greece remain scarce. Material and methods: This was an observational, retrospective study from 6 reference centers between February 26 and May 15, 2020. Results: The patients were mostly males (65.7%) and never smokers (57.2%) of median age 60 (95% CI: 57.6–64) years. The majority of the subjects (98%) were treated with the standard-of-care therapeutic regimen at that time, including hydroxychloroquine and azithromycin. Median time of hospitalization was 10 days (95% CI: 10–12). Twenty-five (13.3%) individuals were intubated and 8 died (4.2%). The patients with high neutrophil-to-lymphocyte ratio (NLR) (> 3.58) exhibited more severe disease as indicated by significantly increased World Health Organization (WHO) R&D ordinal scale (4; 95% CI: 4–4 vs 3; 95% CI: 3–4, p = 0.0001) and MaxFiO2% (50; 95% CI: 38.2–50 vs 29.5; 95% CI: 21–31, p < 0.0001). The patients with increased lactate dehydrogenase (LDH) levels (>270 IU/ml) also exhibited more advanced disease compared to the low LDH group (< 270 IU/ml) as indicated by both WHO R&D ordinal scale (4; 95% CI: 4–4 vs 4; 95% CI: 3–4, p = 0.0001) and MaxFiO2% (50; 95% CI: 35–60 vs 28; 95% CI: 21–31, p < 0.0001). Conclusion: We present the first epidemiological report from a low-incidence and mortality COVID-19 country. NLR and LDH may represent reliable disease prognosticators leading to timely treatment decisions. © 2021 PTChP.
Συγγραφείς:
Tzouvelekis, A.
Akinosoglou, K.
Karampitsakos, T.
Panou, V.
Tomos, I.
Tsoukalas, G.
Stratiki, M.
Dimakou, K.
Chrysikos, S.
Papaioannou, O.
Hillas, G.
Bakakos, P.
Stratakos, G.
Anagnostopoulos, A.
Koromilias, A.
Boutou, A.
Kioumis, I.
Chloros, D.
Kontakiotis, T.
Papakosta, D.
Papiris, S.
Manali, E.
Antonogiannaki, E.-M.
Koulouris, N.
Bouros, D.
Loukides, S.
Gogos, C.
Λέξεις-κλειδιά:
adult; artificial ventilation; diagnosis; female; Greece; human; intensive care; male; middle aged; procedures; severity of illness index; therapy, Adult; COVID-19; Critical Care; Female; Greece; Humans; Male; Middle Aged; Respiration, Artificial; Severity of Illness Index
