Τίτλος:
SARS-CoV-2 seroprevalence in healthcare workers of a Swiss tertiary care centre at the end of the first wave: A cross-sectional study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective To assess the SARS-CoV-2 transmission in healthcare workers (HCWs) using seroprevalence as a surrogate marker of infection in our tertiary care centre according to exposure. Design Seroprevalence cross-sectional study. Setting Single centre at the end of the first COVID-19 wave in Lausanne, Switzerland. Participants 1874 of 4074 responders randomly selected (46% response rate), stratified by work category among the 13 474 (13.9%) HCWs. Main outcome measures Evaluation of SARS-CoV-2 serostatus paired with a questionnaire of SARS-CoV-2 acquisition risk factors internal and external to the workplace. Results The overall SARS-CoV-2 seroprevalence rate among HCWs was 10.0% (95% CI 8.7% to 11.5%). HCWs with daily patient contact did not experience increased rates of seropositivity relative to those without (10.3% vs 9.6%, respectively, p=0.64). HCWs with direct contact with patients with COVID-19 or working in COVID-19 units did not experience increased seropositivity rates relative to their counterparts (10.4% vs 9.8%, p=0.69 and 10.6% vs 9.9%, p=0.69, respectively). However, specific locations of contact with patients irrespective of COVID-19 status - in patient rooms or reception areas - did correlate with increased rates of seropositivity (11.9% vs 7.5%, p=0.019 and 14.3% vs 9.2%, p=0.025, respectively). In contrast, HCWs with a suspected or proven SARS-CoV-2-infected household contact had significantly higher seropositivity rates than those without such contacts (19.0% vs 8.7%, p<0.001 and 42.1% vs 9.4%, p<0.001, respectively). Finally, consistent use of a mask on public transportation correlated with decreased seroprevalence (5.3% for mask users vs 11.2% for intermittent or no mask use, p=0.030). Conclusions The overall seroprevalence was 10% without significant differences in seroprevalence between HCWs exposed to patients with COVID-19 and HCWs not exposed. This suggests that, once fully in place, protective measures limited SARS-CoV-2 occupational acquisition within the hospital environment. SARS-CoV-2 seroconversion among HCWs was associated primarily with community risk factors, particularly household transmission. © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Συγγραφείς:
Meylan, S.
Dafni, U.
Lamoth, F.
Tsourti, Z.
Lobritz, M.A.
Regina, J.
Bressin, P.
Senn, L.
Grandbastien, B.
Andre, C.
Fenwick, C.
D'Acremont, V.
Croxatto, A.
Guilleret, I.
Greub, G.
Manuel, O.
Calandra, T.
Pantaleo, G.
Lazor-Blanchet, C.
Περιοδικό:
BMJ Open Ophthalmology
Εκδότης:
BMJ Publishing Group
Λέξεις-κλειδιά:
SARS-CoV-2 antibody, adult; aerosol generating procedure; anosmia; Article; coronavirus disease 2019; cross-sectional study; disease marker; disinfection; dysgeusia; emergency ward; epidemiological monitoring; female; fever; government; health care personnel; hospital administrator; human; infection risk; intensive care unit; laryngoscopy; major clinical study; male; medical student; medical technology; myalgia; nasopharyngeal swab; nonhuman; noninvasive ventilation; nursing assistant; nursing staff; occupational exposure; overall response rate; physician; prevalence; protective glasses; questionnaire; resuscitation; risk factor; sensitivity and specificity; seroconversion; seroprevalence; Severe acute respiratory syndrome coronavirus 2; social worker; sore throat; Switzerland; symptomatology; tertiary care center; traffic and transport; virus transmission; waste management; epidemiology; health care personnel; seroepidemiology; tertiary care center, COVID-19; Cross-Sectional Studies; Health Personnel; Humans; SARS-CoV-2; Seroepidemiologic Studies; Switzerland; Tertiary Care Centers
DOI:
10.1136/bmjopen-2021-049232
