Τίτλος:
Association between Upper Respiratory Tract Viral Load, Comorbidities, Disease Severity, and Outcome of Patients with SARS-CoV-2 Infection
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: There is limited information on the association between upper respiratory tract (URT) viral loads, host factors, and disease severity in SARS-CoV-2-infected patients. Methods: We studied 1122 patients (mean age, 46 years) diagnosed by polymerase chain reaction (PCR). URT viral load, measured by PCR cycle threshold, was categorized as high, moderate, or low. Results: There were 336 (29.9%) patients with comorbidities; 309 patients (27.5%) had high, 316 (28.2%) moderate, and 497 (44.3%) low viral load. In univariate analyses, compared to patients with moderate or low viral load, patients with high viral load were older, more often had comorbidities, developed Symptomatic disease (COVID-19), were intubated, and died. Patients with high viral load had longer stay in intensive care unit and longer intubation compared to patients with low viral load (P values†<†.05 for all comparisons). Patients with chronic cardiovascular disease, hypertension, chronic pulmonary disease, immunosuppression, obesity, and chronic neurological disease more often had high viral load (P value†<†.05 for all comparisons). In multivariate analysis high viral load was associated with COVID-19. Level of viral load was not associated with any other outcome. Conclusions: URT viral load could be used to identify patients at higher risk for morbidity or severe outcome. © 2021 The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
Συγγραφείς:
Maltezou, H.C.
Raftopoulos, V.
Vorou, R.
Papadima, K.
Mellou, K.
Spanakis, N.
Kossyvakis, A.
Gioula, G.
Exindari, M.
Froukala, E.
Martinez-Gonzalez, B.
Panayiotakopoulos, G.
Papa, A.
Mentis, A.
Tsakris, A.
Περιοδικό:
JOURNAL OF INFECTIOUS DISEASES
Εκδότης:
Oxford University Press
Λέξεις-κλειδιά:
adult; age; aged; Article; asymptomatic coronavirus disease 2019; cardiovascular disease; chronic disease; chronic lung disease; clinical outcome; comorbidity; comparative study; coronavirus disease 2019; cycle threshold value; death; disease severity; female; human; hypertension; immune deficiency; intensive care unit; intubation; length of stay; major clinical study; male; morbidity; multivariate analysis; neurologic disease; obesity; polymerase chain reaction; risk assessment; Severe acute respiratory syndrome coronavirus 2; univariate analysis; upper respiratory tract; virus load; adolescent; artificial ventilation; child; comorbidity; diagnosis; endotracheal intubation; infant; isolation and purification; middle aged; mortality; nasopharynx; newborn; oropharynx; preschool child; prospective study; severity of illness index; therapy; very elderly; virology; virus load; young adult, Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Comorbidity; COVID-19; COVID-19 Nucleic Acid Testing; Female; Humans; Infant; Infant, Newborn; Intensive Care Units; Intubation, Intratracheal; Length of Stay; Male; Middle Aged; Nasopharynx; Oropharynx; Prospective Studies; Respiration, Artificial; SARS-CoV-2; Severity of Illness Index; Viral Load; Young Adult
DOI:
10.1093/infdis/jiaa804
