Τίτλος:
Comparison of two different sedation protocols during transvaginal oocyte retrieval: Effects on propofol consumption and ivf outcome: A prospective cohort study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
(1) Background: There has been various reports on the potential impact of anesthetic agents used during oocyte retrieval (OR) on the impairment of the capacity of the oocyte for fertilization and subsequent embryo quality; results have been conflicting; (2) Methods: The effects of two different sedation protocols during OR in two groups of patients undergoing In Vitro Fertili-zation/Intra‐Cytoplasmic Sperm Injection IVF/ICSI, were compared on propofol consumption and on in vitro fertilization (IVF)/ICSI success. The study group received dexmedetomidine and fen-tanyl, while the control remifentanil and midazolam. In a prospective cohort study, we encom-passed 72 cycles/patients. The administered dose of propofol per patient and fertilization rates were the primary outcomes, while anesthesiological parameters and IVF/ICSI outcomes were the secondary endpoints; (3) Results: We found a significant increase in propofol consumption in the study compared to the control group (77.0 ± 10.6 mg vs. 12.1 ± 6.1; p < 0.001), but fertilization rates were similar (p = 0.469). From the secondary anesthesiological outcomes, the post anesthesia dis-charge scores were better in the control group (15.0 (13.5 min) vs. 5.0 (10.0 min), p = 0.028). From the IVF/ICSI secondary outcome parameters, we found a higher quality of embryos on day three in the study compared to the control group (p = 0.040). The comparison of the other secondary outcomes yielded non‐significant differences; (4) Conclusions: The use of dexmedetomidine, as an alternative agent during OR, was associated with higher propofol consumption as a rescue dose compared to remifentanil but was linked with similar fertilization rates and higher quality of embryos pro-duced. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Συγγραφείς:
Matsota, P.
Sidiropoulou, T.
Vrantza, T.
Boutsikou, M.
Midvighi, E.
Siristatidis, C.
Περιοδικό:
Journal of Clinical Medicine Research
Λέξεις-κλειδιά:
dexmedetomidine; fentanyl; midazolam; propofol; remifentanil, adult; anesthesia; Article; clinical article; clinical protocol; cohort analysis; comparative study; conscious sedation; continuous infusion; controlled study; drug use; female; hospital discharge; human; in vitro fertilization; intracytoplasmic sperm injection; oocyte retrieval; prospective study
