Τίτλος:
Glycated Hemoglobin (HbA1c) as a Predictor of Outcomes during Acute Exacerbations of Chronic Obstructive Pulmonary Disease
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Systemic inflammation may be the common denominator between COPD and type 2 diabetes and may explain the correlation in both diseases’ development and progress. The aim of this prospective observational study is to examine the prognostic value of glycated hemoglobin levels (HbA1c) and HbA1c-adjusted glycemic variables (glycemic gap, stress hyperglycemia ratio και modified stress hyperglycemia ratio) in an acute exacerbation of COPD (AECOPD) as well as in COPD disease's morbidity and mortality during the following year. We evaluated patients hospitalized only for COPD exacerbations. Levels of HbA1c and HbA1c-adjusted glycemic variables were recorded upon admission. The study outcomes included duration of hospital stay, need for mechanical ventilation and exacerbation outcome. All subjects were followed up for one year. A total of 156 patients were included in the study (74.4% men, age [mean ± SD] 72 ± 7 years). Patients (21.8%) had type 2 diabetes and 67.9% of patients were receiving ICS treatment. The median value of HbA1c was 5.9 (IQR: 5.4, 6.5). Necessity for mechanical ventilation was significantly higher for patients with lower values of HbA1c [median: 5.3 (IQR 5.02, 6.3) vs. 5.9 (IQR 5.5, 6.5), p =.038]. However, duration of hospitalization, death during hospitalization as well as the number of new exacerbation events, time to next exacerbation and mortality during the following year did not differ significantly. Moreover, none of the HbA1c-adjusted glycemic variables examined, demonstrated any statistical significance. In conclusion neither the preceding nor the present glycemic state exhibit a predictive value regarding short- or long-term outcomes of an AECOPD. © 2021 Taylor & Francis Group, LLC.
Συγγραφείς:
Papathanassiou, E.
Papaioannou, A.I.
Papanikolaou, I.
Antonakis, E.
Makou, I.
Hillas, G.
Mizi, E.
Bakakos, P.
Apollonatou, V.
Verykokou, G.
Roussakis, N.
Tsilogianni, Z.
Papiris, S.
Loukides, S.
Περιοδικό:
COPD: Journal of Chronic Obstructive Pulmonary Disease
Εκδότης:
Taylor and Francis Ltd.
Λέξεις-κλειδιά:
beta 2 adrenergic receptor stimulating agent; corticosteroid; hemoglobin A1c; muscarinic receptor blocking agent; glycosylated hemoglobin, aged; Article; artificial ventilation; chronic obstructive lung disease; clinical outcome; controlled study; death; disease exacerbation; female; follow up; hemoglobin blood level; hospital admission; hospital mortality; hospitalization; human; hyperglycemia; length of stay; major clinical study; male; morbidity; non insulin dependent diabetes mellitus; observational study; priority journal; prognosis; prospective study; chronic obstructive lung disease; complication; disease exacerbation; glucose blood level; hyperglycemia; non insulin dependent diabetes mellitus, Aged; Blood Glucose; Diabetes Mellitus, Type 2; Disease Progression; Female; Glycated Hemoglobin A; Hospitalization; Humans; Hyperglycemia; Male; Pulmonary Disease, Chronic Obstructive
DOI:
10.1080/15412555.2021.1902491
