Τίτλος:
A novel optical biosensor for the early diagnosis of sepsis and severe Covid-19: the PROUD study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: The accuracy of a new optical biosensor (OB) point-of-care device for the detection of severe infections is studied. Methods: The OB emits different wavelengths and outputs information associated with heart rate, pulse oximetry, levels of nitric oxide and kidney function. At the first phase, recordings were done every two hours for three consecutive days after hospital admission in 142 patients at high-risk for sepsis by placing the OB on the forefinger. At the second phase, single recordings were done in 54 patients with symptoms of viral infection; 38 were diagnosed with COVID-19. Results: At the first phase, the cutoff value of positive likelihood of 18 provided 100% specificity and 100% positive predictive value for the diagnosis of sepsis. These were 87.5 and 91.7% respectively at the second phase. OB diagnosed severe COVID-19 with 83.3% sensitivity and 87.5% negative predictive value. Conclusions: The studied OB seems valuable for the discrimination of infection severity. © 2020, The Author(s).
Συγγραφείς:
Doulou, S.
Leventogiannis, K.
Tsilika, M.
Rodencal, M.
Katrini, K.
Antonakos, N.
Kyprianou, M.
Karofylakis, E.
Karageorgos, A.
Koufargyris, P.
Christopoulos, G.
Kassianidis, G.
Stamatelopoulos, K.
Newberry, R.
Giamarellos-Bourboulis, E.J.
Περιοδικό:
BMC Infectious Diseases
Εκδότης:
BioMed Central Ltd.
Λέξεις-κλειδιά:
nitric oxide, adult; aged; algorithm; Article; controlled study; coronavirus disease 2019; diagnostic test accuracy study; disease severity; early diagnosis; female; heart rate; high risk patient; hospital admission; human; index finger; kidney function; major clinical study; male; phase 1 clinical trial; phase 2 clinical trial; photoelectric plethysmography; predictive value; pulse oximetry; reference value; sensitivity and specificity; sepsis; symptom; area under the curve; Betacoronavirus; Coronavirus infection; early diagnosis; genetic procedures; isolation and purification; laboratory technique; middle aged; pandemic; pathology; procedures; receiver operating characteristic; sepsis; severity of illness index; very elderly; virology; virus pneumonia, Aged; Aged, 80 and over; Algorithms; Area Under Curve; Betacoronavirus; Biosensing Techniques; Clinical Laboratory Techniques; Coronavirus Infections; Early Diagnosis; Female; Humans; Male; Middle Aged; Pandemics; Pneumonia, Viral; ROC Curve; Sensitivity and Specificity; Sepsis; Severity of Illness Index
DOI:
10.1186/s12879-020-05607-1
