Περίληψη:
Background: Thin nodular melanoma (NM) often lacks conspicuous melanoma-specific dermatoscopic criteria and escapes clinical detection until it progresses to a thicker and more advanced tumour. Objective: To investigate the dermatoscopic morphology of thin (≤2 mm Breslow thickness) vs. thick (>2 mm) NM and to identify dermatoscopic predictors of its differential diagnosis from other nodular tumours. Methods: Retrospective, morphological case–control study, conducted on behalf of the International Dermoscopy Society. Dermatoscopic images of NM and other nodular tumours from 19 skin cancer centres worldwide were collected and analysed. Results: Overall, 254 tumours were collected (69 NM of Breslow thickness ≤2 mm, 96 NM >2 mm and 89 non-melanoma nodular lesions). Light brown coloration (50.7%) and irregular brown dots/globules (42.0%) were most frequently observed in ≤2 mm NMs. Multivariate analysis revealed that dotted vessels (3.4-fold), white shiny streaks (2.9-fold) and irregular blue structureless area (2.4-fold) were predictors for thinner NM compared to non-melanoma nodular tumours. Overall, irregular blue structureless area (3.4-fold), dotted vessels (4.6-fold) and serpentine vessels (1.9-fold) were predictors of all NM compared to non-melanoma nodular lesions. Limitations: Absence of a centralized, consensus pathology review and cases selected form tertiary centres maybe not reflecting the broader community. Conclusions: Our study sheds light into the dermatoscopic morphology of thin NM in comparison to thicker NM and could provide useful clues for its differential diagnosis from other non-melanoma nodular tumours. © 2020 European Academy of Dermatology and Venereology
Συγγραφείς:
Sgouros, D.
Lallas, A.
Kittler, H.
Zarras, A.
Kyrgidis, A.
Papageorgiou, C.
Puig, S.
Scope, A.
Argenziano, G.
Zalaudek, I.
Pizzichetta, M.A.
Marghoob, A.
Liopyris, K.
Malvehy, J.
Oikonomou, C.
Flórez, A.
Braun, R.
Cabo, H.
Nazzaro, G.
Lanssens, S.
Menzies, S.
Paoli, J.
Kaminska – Winciorek, G.
Longo, C.
Katoulis, A.
Apalla, Z.
Ioannides, D.
Thomas, L.
Tromme, I.
Ogata, D.
Desinioti, C.
Geller, A.
Stratigos, A.
Λέξεις-κλειδιά:
adolescent; adult; aged; angioma; Article; basal cell carcinoma; benign neoplasm; Breslow thickness; cancer center; cancer localization; case control study; collaborative care team; community; consensus; controlled study; differential diagnosis; female; histopathology; human; image analysis; major clinical study; male; medical society; melanoma; morphology; multivariate analysis; nevus; prediction; priority journal; retrospective study; seborrheic keratosis; sex ratio; skin color; skin nodule; skin tumor; squamous cell carcinoma; tertiary care center; thickness; diagnostic imaging; epiluminescence microscopy; melanoma; skin tumor, Case-Control Studies; Dermoscopy; Humans; Melanoma; Retrospective Studies; Skin Neoplasms
