Τίτλος:
SARS-CoV-2/COVID-19: Evolving Reality, Global Response, Knowledge Gaps, and Opportunities
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Approximately 3 billion people around the world have gone into some form of social separation to mitigate the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. The uncontrolled influx of patients in need of emergency care has rapidly brought several national health systems to near-collapse with deadly consequences to those afflicted by Coronavirus Disease 2019 (COVID-19) and other critical diseases associated with COVID-19. Solid scientific evidence regarding SARS-CoV-2/COVID-19 remains scarce; there is an urgent need to expand our understanding of the SARS-CoV-2 pathophysiology to facilitate precise and targeted treatments. The capacity for rapid information dissemination has emerged as a double-edged sword; the existing gap of high-quality data is frequently filled by anecdotal reports, contradictory statements, and misinformation. This review addresses several important aspects unique to the SARS-CoV-2/COVID-19 pandemic highlighting the most relevant knowledge gaps and existing windows-of-opportunity. Specifically, focus is given on SARS-CoV-2 immunopathogenesis in the context of experimental therapies and preclinical evidence and their applicability in supporting efficacious clinical trial planning. The review discusses the existing challenges of SARS-CoV-2 diagnostics and the potential application of translational technology for epidemiological predictions, patient monitoring, and treatment decision-making in COVID-19. Furthermore, solutions for enhancing international strategies in translational research, cooperative networks, and regulatory partnerships are contemplated.
Συγγραφείς:
Osuchowski, M.F.
Aletti, F.
Cavaillon, J.-M.
Flohé, S.B.
Giamarellos-Bourboulis, E.J.
Huber-Lang, M.
Relja, B.
Skirecki, T.
Szabó, A.
Maegele, M.
Περιοδικό:
Shock (Augusta, Ga.)
Λέξεις-κλειδιά:
Betacoronavirus; clinical trial (topic); Coronavirus infection; human; laboratory technique; pandemic; virus pneumonia, Betacoronavirus; Clinical Laboratory Techniques; Clinical Trials as Topic; Coronavirus Infections; Humans; Pandemics; Pneumonia, Viral
DOI:
10.1097/SHK.0000000000001565
