Τίτλος:
Acute effects of e-cigarette vaping on pulmonary function and airway inflammation in healthy individuals and in patients with asthma
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background and objective: The acute effects of e-cigarettes have not been scientifically demonstrated yet. The aim of this study was to assess the acute changes in pulmonary function and airway inflammation in patients with asthma after vaping one e-cigarette. Methods: Twenty-five smokers suffering from stable moderate asthma according to GINA guidelines with no other comorbidities and 25 healthy smokers matched with the baseline characteristics of the asthmatic patients were recruited. PFT, IOS, FeNO and EBC were performed before and after vaping one e-cigarette with nicotine. pH and concentrations of IL-1β, IL-4, IL-5, IL-6, IL-8, IL-10, IL-13, IL-17A, TNF-α, ISO8 and LTB4 were measured in EBC. Results: FFEV1/FVC ratio and PEF were reduced in asthmatic patients after e-cigarette. Z5Hz and R5Hz, R10Hz and R20Hz increased in both groups. FeNO and EBC pH increased by 3.60 ppb (P = 0.001) and 0.15 (P = 0.014) in asthmatic patients after e-cigarette, whereas they decreased in control group by 3.28 ppb (P ' 0.001) and 0.12 (P = 0.064), respectively. The concentrations of IL-10, TNF-α and ISO8 in EBC increased in asthmatic patients after e-cigarette and the changes in concentrations of IL-1β and IL-4 differed significantly between the two groups. Conclusion: E-cigarette vaping resulted in acute alteration of both pulmonary function and airway inflammation in stable moderate asthmatic patients. © 2020 Asian Pacific Society of Respirology
Συγγραφείς:
Kotoulas, S.-C.
Pataka, A.
Domvri, K.
Spyratos, D.
Katsaounou, P.
Porpodis, K.
Fouka, E.
Markopoulou, A.
Passa-Fekete, K.
Grigoriou, I.
Kontakiotis, T.
Argyropoulou, P.
Papakosta, D.
Εκδότης:
Blackwell Publishing Inc.
Λέξεις-κλειδιά:
8 isoprostane; beta 2 adrenergic receptor stimulating agent; corticosteroid; interleukin 10; interleukin 13; interleukin 17; interleukin 1beta; interleukin 4; interleukin 5; interleukin 6; interleukin 8; leukotriene B4; long acting drug; tumor necrosis factor; autacoid, adult; Article; asthma; clinical article; controlled study; enzyme linked immunosorbent assay; exhaled breath condensate; female; forced expiratory volume; forced vital capacity; fractional exhaled nitric oxide; functional residual capacity; human; low drug dose; lung capacity; lung function; lung ventilation; male; maximal expiratory flow; peak expiratory flow; pH measurement; priority journal; protein analysis; respiratory tract inflammation; respiratory tract parameters; total lung capacity; vaping; asthma; case control study; electronic cigarette; lung; lung function test; metabolism; pathophysiology; pneumonia, Adult; Asthma; Case-Control Studies; Electronic Nicotine Delivery Systems; Female; Humans; Inflammation Mediators; Lung; Male; Pneumonia; Respiratory Function Tests; Vaping
