Περίληψη:
The coronavirus disease 2019 (COVID-19) pandemic has posed a significant challenge to physicians and healthcare systems worldwide. Evidence about kidney transplant (KTx) recipients is still limited. A systematic literature review was performed. We included 63 articles published from 1 January until 7 July 2020, reporting on 420 adult KTx recipients with confirmed COVID-19. The mean age of patients was 55 ± 15 years. There was a male predominance (67%). The majority (74%) were deceased donor recipients, and 23% were recently transplanted (<1 year). Most patients (88%) had at least one comorbidity, 29% had two, and 18% three. Ninety-three percent of cases were hospitalized. Among them, 30% were admitted to the intensive care unit, 45% developed acute respiratory distress syndrome, and 44% had acute kidney injury with 23% needing renal replacement therapy. From the hospitalized patients a total of 22% died, 59% were discharged, and 19% were still in hospital at the time of publication. Immunosuppression was reduced in 27%, discontinued in 31%, and remained unchanged in 5%. Hydroxychloroquine was administered to 78% of patients, antibiotics to 73%, and antivirals to 30% while 25% received corticosteroid boluses, 28% received anti-interleukin agents, and 8% were given immunoglobulin. The main finding of our analysis was that the incidence of COVID-19 among kidney transplant patients is not particularly high, but when they do get infected, this is related to significant morbidity and mortality. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Συγγραφείς:
Marinaki, S.
Tsiakas, S.
Korogiannou, M.
Grigorakos, K.
Papalois, V.
Boletis, I.
Λέξεις-κλειδιά:
corticosteroid; cytokine receptor antagonist; hydroxychloroquine; immunoglobulin, acute kidney failure; adult respiratory distress syndrome; antibiotic therapy; antiviral therapy; comorbidity; coronavirus disease 2019; corticosteroid therapy; deceased donor; disease course; disease severity; graft recipient; hospital discharge; hospital mortality; hospital patient; hospitalization; human; immunosuppressive treatment; infection rate; intensive care unit; kidney allograft; kidney transplantation; renal replacement therapy; Review; systematic review
