Τίτλος:
The Role of Low Dose Whole Body CT in the Detection of Progression of Patients with Smoldering Multiple Myeloma
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Multiple myeloma (MM) is the second most common hematological malignancy, characterized by plasma cell bone marrow infiltration and end-organ involvement. Smoldering MM (SMM) is an intermediate clinical entity between MGUS and MM, with a risk of progression to symptomatic disease 10% per year. Bone disease is the most frequent symptom of MM, with ~90% of patients developing bone lesions throughout their disease course. Therefore, imaging plays a crucial role in diagnosis and management. Whole-body low-dose CT (WBLDCT) is widely available and has been incorporated in the latest diagnostic criteria of the IMWG. The purpose of this study was to evaluate the role of WBLDCT in the early identification of lesions in patients with SMM who progress solely with bone disease. In total, 100 asymptomatic patients were consecutively assessed with WBLDCT from July 2013 until March 2020 at baseline, 1-year after diagnosis and every 1 year thereafter. Ten percent of patients were identified as progressors with this single imaging modality. This is the first study to evaluate prospectively patients with SMM at different time points to identify early bone lesions related to MM evolution. Serial WBLDCT studies can identify early myeloma evolution and optimize disease monitoring and therapeutic strategies. © 2020, The Author(s).
Συγγραφείς:
Gavriatopoulou, M.
Βoultadaki, A.
Koutoulidis, V.
Ntanasis-Stathopoulos, I.
Bourgioti, C.
Malandrakis, P.
Fotiou, D.
Migkou, M.
Kanellias, N.
Eleutherakis-Papaiakovou, E.
Kastritis, E.
Terpos, E.
Dimopoulos, M.A.
Moulopoulos, L.-A.
Περιοδικό:
Blood cancer journal
Εκδότης:
Springer Nature BV
Λέξεις-κλειδιά:
adult; aged; Article; bone disease; cancer growth; disease course; female; human; incidentaloma; major clinical study; male; prospective study; smoldering multiple myeloma; very elderly; whole body CT; x-ray computed tomography; bone disease; clinical trial; diagnostic imaging; disease exacerbation; middle aged; smoldering multiple myeloma; x-ray computed tomography, Adult; Aged; Aged, 80 and over; Bone Diseases; Disease Progression; Female; Humans; Male; Middle Aged; Smoldering Multiple Myeloma; Tomography, X-Ray Computed
DOI:
10.1038/s41408-020-00360-9
