Τίτλος:
Sex-discrete role of depressive symptomatology on 10-year first and recurrent cardiovascular disease incidence: results from ATTICA and GREECS prospective studies
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: The sex-specific effect of depressive symptomatology on 10-year first and recurrent cardiovascular disease (CVD) events was evaluated. Methods: The Greek samples from ATTICA (2002-2012, n = 845 free-of-CVD subjects) and GREECS (2004-2014, n = 2,172 subjects with acute coronary syndrome (ACS)) prospective epidemiological studies with baseline psychological assessments were used for the first and the recurrent event, respectively. Depressive symptomatology was assessed at baseline, through Zung Self-Rating Depression Scale in the ATTICA study, and through the Center for Epidemiological Studies-Depression scale in the GREECS study. Results: ACS as well as free-of-CVD women scored significantly higher for depressive symptomatology. Men scored higher than women against first (19.7% vs. 11.7%) and subsequent CVD events (38.8% vs. 32.9%). In participants with depressive symptoms man-to-woman first and recurrent CVD event rate ratio was below 1, confirming that depressive women were more likely to have a CVD event than depressive men. Multiadjusted analysis revealed that depressive symptomatology had an independent aggravating effect on the first (hazard ratio (HR) = 2.72, 95% confidence interval (95% CI) 1.50, 9.12) and recurrent (HR = 1.31, 95% CI 1.01, 1.69) CVD events only in women. Mediation analysis in women revealed that 35% (23%, 44%) of excess first-CVD-event risk of depressive symptoms was attributed to conventional risk factors. The respective number for recurrent CVD events was 46% (23%, 53%); different patterns of ranking regarding the mediating effect corresponding to each adjustment factor were observed. Conclusions: The present work augments prior evidence that psychological stressors possess important drivers of CVD onset and progression mainly in women, while it gives rise to research toward unidentified paths behind this claim. © 2019 Hellenic Society of Cardiology
Συγγραφείς:
Kouvari, M.
Panagiotakos, D.B.
Chrysohoou, C.
Notara, V.
Georgousopoulou, E.
Tousoulis, D.
Pitsavos, C.
the ATTICA & GREECS Studies Investigators
Περιοδικό:
Ελληνική καρδιολογική επιθεώρηση
Εκδότης:
Hellenic Cardiological Society
Λέξεις-κλειδιά:
C reactive protein; cholesterol; high density lipoprotein; interleukin 6; low density lipoprotein; triacylglycerol, acute coronary syndrome; adult; aged; anthropometry; Article; body mass; cardiovascular disease; cardiovascular risk; Center for Epidemiological Studies Depression Scale; cohort analysis; controlled study; depression; diabetes mellitus; disease association; female; follow up; hip circumference; human; hypercholesterolemia; hypertension; lifestyle and related phenomena; major clinical study; male; Mediterranean diet; mental stress; middle aged; observational study; physical activity; prospective study; psychologic assessment; risk factor; Self Reporting Questionnaire 20; sex difference; smoking; waist circumference; waist hip ratio; Zung Self Rating Anxiety Scale; cardiovascular disease; chronic disease; depression; incidence, Acute Coronary Syndrome; Cardiovascular Diseases; Chronic Disease; Depression; Female; Humans; Incidence; Male; Prospective Studies; Risk Factors
DOI:
10.1016/j.hjc.2019.10.017
