Τίτλος:
Systematic Review and Meta-Analysis of Outcomes of Open and Endovascular Repair of Ruptured Abdominal Aortic Aneurysm in Patients with Hostile vs. Friendly Aortic Anatomy
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: To investigate the effect of hostile aortic anatomy on the outcomes of endovascular and open repair for ruptured abdominal aortic aneurysm (AAA). Methods: Electronic bibliographic sources (MEDLINE, EMBASE, CENTRAL) were searched using a combination of thesaurus and free text terms to identify studies comparing treatment outcomes of ruptured AAA in patients with hostile vs. friendly aortic anatomy. A systematic review was conducted that conformed to the PRISMA guidelines using a registered protocol (CRD42019127307). The primary outcomes were peri-operative mortality, freedom from aneurysm related mortality, and overall survival. Pooled estimates of dichotomous outcomes were calculated using odds ratio (OR) and 95% confidence interval (CI). A time to event data meta-analysis was conducted using the inverse variance method and the results were reported as summary hazard ratio (HR) and associated 95% CI. Subgroup analysis for type of treatment (endovascular aneurysm repair [EVAR] or open repair) was undertaken. Random effects models of meta-analysis were developed. Results: Ten observational studies were included reporting a total of 1284 patients (748 with hostile anatomy and 536 with friendly anatomy). Patients with hostile anatomy had a higher peri-operative mortality than patients with friendly anatomy (OR 1.73, 95% CI 1.13–2.66; p =.01). Subgroup analysis showed a significant difference in peri-operative mortality in favour of friendly anatomy in patients treated by EVAR (OR 1.76, 95% CI 1.01–3.08; p =.05), but not in those treated by open repair (OR 1.37, 95% CI 0.83–2.27; p =.22). Patients with hostile anatomy treated by EVAR had a significantly higher hazard of death in follow up than patients with friendly aortic anatomy (HR 2.01, 95% CI 1.18–3.44, p =.01), whereas for open surgical repair, the survival was similar in patients with hostile and those with friendly aortic anatomy (HR 0.90, 95% CI 0.61–1.32, p =.58). Conclusion: Hostile aortic anatomy is associated with increased mortality in patients with ruptured AAA treated by EVAR. © 2019 European Society for Vascular Surgery
Συγγραφείς:
Kontopodis, N.
Tavlas, E.
Ioannou, C.V.
Giannoukas, A.D.
Geroulakos, G.
Antoniou, G.A.
Περιοδικό:
European Journal of Vascular and Endovascular Surgery
Εκδότης:
W.B. Saunders Ltd
Λέξεις-κλειδιά:
abdominal aortic aneurysm; anatomy; aorta; endovascular aneurysm repair; human; meta analysis; open surgery; overall survival; post treatment survival; priority journal; Review; surgical mortality; systematic review; treatment outcome; abdominal aortic aneurysm; anatomy and histology; aorta; aortic rupture; comparative study; endovascular surgery; treatment outcome, Aorta; Aortic Aneurysm, Abdominal; Aortic Rupture; Endovascular Procedures; Humans; Treatment Outcome
DOI:
10.1016/j.ejvs.2019.12.024
