Τίτλος:
The Alzheimer's Disease Amyloid-Beta Hypothesis in Cardiovascular Aging and Disease: JACC Focus Seminar
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Aging-related cellular and molecular processes including low-grade inflammation are major players in the pathogenesis of cardiovascular disease (CVD) and Alzheimer's disease (AD). Epidemiological studies report an independent interaction between the development of dementia and the incidence of CVD in several populations, suggesting the presence of overlapping molecular mechanisms. Accumulating experimental and clinical evidence suggests that amyloid-beta (Aβ) peptides may function as a link among aging, CVD, and AD. Aging-related vascular and cardiac deposition of Αβ induces tissue inflammation and organ dysfunction, both important components of the Alzheimer's disease amyloid hypothesis. In this review, the authors describe the determinants of Aβ metabolism, summarize the effects of Aβ on atherothrombosis and cardiac dysfunction, discuss the clinical value of Αβ1-40 in CVD prognosis and patient risk stratification, and present the therapeutic interventions that may alter Aβ metabolism in humans. © 2020 The Authors
Συγγραφείς:
Stakos, D.A.
Stamatelopoulos, K.
Bampatsias, D.
Sachse, M.
Zormpas, E.
Vlachogiannis, N.I.
Tual-Chalot, S.
Stellos, K.
Περιοδικό:
Journal of the American College of Cardiology
Εκδότης:
ELSEVIER SCIENCE INC 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
Λέξεις-κλειδιά:
amyloid beta protein[1-40]; amyloid beta protein[1-42]; anticoagulant agent; apolipoprotein E; apolipoprotein E4; beta secretase 1; cystatin C; endothelial nitric oxide synthase; high density lipoprotein; low density lipoprotein receptor related protein; reactive oxygen metabolite; telomerase; amyloid beta protein, aging; Alzheimer disease; angiogenesis; bioaccumulation; cardiovascular disease; cell viability; coronary artery disease; deterioration; disease association; endothelium cell; enzyme activity; enzyme inhibition; heart failure; heart function; human; lifestyle modification; mortality; nonhuman; pathogenesis; population research; priority journal; prognosis; protein aggregation; protein blood level; protein expression; protein function; protein metabolism; Review; risk factor; smooth muscle cell; aging; Alzheimer disease; animal; cardiovascular disease; metabolism; physiology; risk assessment, Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cardiovascular Diseases; Humans; Mortality; Risk Assessment
DOI:
10.1016/j.jacc.2019.12.033
