Τίτλος:
Intravascular Polarimetry in Patients With Coronary Artery Disease
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objectives: The aims of this first-in-human pilot study of intravascular polarimetry were to investigate polarization properties of coronary plaques in patients and to examine the relationship of these features with established structural characteristics available to conventional optical frequency domain imaging (OFDI) and with clinical presentation. Background: Polarization-sensitive OFDI measures birefringence and depolarization of tissue together with conventional cross-sectional optical frequency domain images of subsurface microstructure. Methods: Thirty patients undergoing polarization-sensitive OFDI (acute coronary syndrome, n = 12; stable angina pectoris, n = 18) participated in this study. Three hundred forty-two cross-sectional images evenly distributed along all imaged coronary arteries were classified into 1 of 7 plaque categories according to conventional OFDI. Polarization features averaged over the entire intimal area of each cross section were compared among plaque types and with structural parameters. Furthermore, the polarization properties in cross sections (n = 244) of the fibrous caps of acute coronary syndrome and stable angina pectoris culprit lesions were assessed and compared with structural features using a generalized linear model. Results: The median birefringence and depolarization showed statistically significant differences among plaque types (p < 0.001 for both, one-way analysis of variance). Depolarization differed significantly among individual plaque types (p < 0.05), except between normal arteries and fibrous plaques and between fibrofatty and fibrocalcified plaques. Caps of acute coronary syndrome lesions and ruptured caps exhibited lower birefringence than caps of stable angina pectoris lesions (p < 0.01). In addition to clinical presentation, cap birefringence was also associated with macrophage accumulation as assessed using normalized SD. Conclusions: Intravascular polarimetry provides quantitative metrics that help characterize coronary arterial tissues and may offer refined insight into coronary arterial atherosclerotic lesions in patients. © 2020 The Authors
Συγγραφείς:
Otsuka, K.
Villiger, M.
Karanasos, A.
van Zandvoort, L.J.C.
Doradla, P.
Ren, J.
Lippok, N.
Daemen, J.
Diletti, R.
van Geuns, R.-J.
Zijlstra, F.
van Soest, G.
Dijkstra, J.
Nadkarni, S.K.
Regar, E.
Bouma, B.E.
Περιοδικό:
JACC Cardiovascular Imaging
Εκδότης:
HANLEY & BELFUS-ELSEVIER INC
Λέξεις-κλειδιά:
acute coronary syndrome; adult; Article; atherosclerotic plaque; bioaccumulation; birefringence; cardiac imaging; clinical article; controlled study; coronary artery atherosclerosis; depolarization; female; heart muscle ischemia; human; macrophage; male; middle aged; optical frequency domain imaging; pilot study; polarimetry; polarization; priority journal; stable angina pectoris; acute coronary syndrome; aged; comparative study; coronary artery disease; coronary blood vessel; cross-sectional study; diagnostic imaging; fibrosis; percutaneous coronary intervention; predictive value; rupture; scanning laser polarimetry; stable angina pectoris, Acute Coronary Syndrome; Aged; Angina, Stable; Coronary Artery Disease; Coronary Vessels; Cross-Sectional Studies; Female; Fibrosis; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Pilot Projects; Plaque, Atherosclerotic; Predictive Value of Tests; Rupture, Spontaneous; Scanning Laser Polarimetry
DOI:
10.1016/j.jcmg.2019.06.015
