Τίτλος:
Perioperative radiotherapy versus surgery alone for retroperitoneal sarcomas: A systematic review and meta-analysis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
There is no clear evidence on whether radiotherapy (RT) improves treatment result in patients with retroperitoneal sarcomas (RPS). A systematic literature search was performed using PubMed, Scopus and CENTRAL databases. Data were retrieved from published comparatives studies in patients with RPS undergoing surgery alone or RT plus surgery. The primary endpoints were the 5-year OS and the median OS. The secondary endpoints were the recurrence-free survival (RFS) and the R0-resection rate. Continuous outcomes were calculated by means of weighted mean difference (WMD). Ten out of 374 articles were analyzed. The median OS and the 5-year survival were significantly increased in patients treated with RT and surgery, compared to patients treated with surgery alone (p < 0.00001, p < 0.001). Median RFS was significantly increased in patients treated with either preoperative (p < 0.001) or postoperative (p = 0.001) RT compared to patients that underwent surgery alone. Finally, median R0-resection rate was similar between the two groups (p = 0.56). RT along with radical surgery could be the standard of care in at least a subgroup of patients with RPS. © 2020 2020 Alexandros Diamantis, Ioannis Baloyiannis, Dimitrios E. Magouliotis, Maria Tolia, Dimitrios Symeonidis, Effrosyni Bompou, Georgios Polymeneas, Konstantinos Tepetes, published by Sciendo.
Συγγραφείς:
Diamantis, A.
Baloyiannis, I.
Magouliotis, D.E.
Tolia, M.
Symeonidis, D.
Bompou, E.
Polymeneas, G.
Tepetes, K.
Περιοδικό:
Radiology and Oncology
Λέξεις-κλειδιά:
Article; cancer control; cancer radiotherapy; cancer recurrence; cancer surgery; human; meta analysis; neoadjuvant therapy; overall survival; perioperative period; postoperative period; recurrence free survival; retroperitoneal sarcoma; survival rate; systematic review; disease free survival; mortality; multimodality cancer therapy; procedures; publishing; retroperitoneal tumor; sarcoma; surgical margin; time factor, Combined Modality Therapy; Disease-Free Survival; Humans; Margins of Excision; Publication Bias; Retroperitoneal Neoplasms; Sarcoma; Time Factors
DOI:
10.2478/raon-2020-0012
