Τίτλος:
Lung microbiome in asthma: Current perspectives
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
A growing body of evidence implicates the human microbiome as a potentially influential player actively engaged in shaping the pathogenetic processes underlying the endotypes and phenotypes of chronic respiratory diseases, particularly of the airways. In this article, we specifically review current evidence on the characteristics of lung microbiome, and specifically the bacteriome, the modes of interaction between lung microbiota and host immune system, the role of the “lung-gut axis”, and the functional effects thereof on asthma pathogenesis. We also attempt to explore the possibilities of therapeutic manipulation of the microbiome, aiming at the establishment of asthma prevention strategies and the optimization of asthma treatment. © 2019, MDPI AG. All rights reserved.
Συγγραφείς:
Loverdos, K.
Bellos, G.
Kokolatou, L.
Vasileiadis, I.
Giamarellos, E.
Pecchiari, M.
Koulouris, N.
Koutsoukou, A.
Rovina, N.
Περιοδικό:
Journal of Clinical Medicine Research
Λέξεις-κλειδιά:
aromatic amino acid; corticosteroid; histone deacetylase; macrophage derived chemokine; macrophage inflammatory protein 1alpha; matrix metalloproteinase; nitric oxide; pathogen associated molecular pattern; pattern recognition receptor; peptidoglycan; reactive oxygen metabolite; short chain fatty acid; toll like receptor; transcription factor RUNX2, Actinobacteria; asthma; Asthma Control Questionnaire; bacterial flora; bacterial genome; Bacteroidetes; chronic obstructive lung disease; dysbiosis; Firmicutes; forced expiratory volume; Fusobacteria; Haemophilus; human; immune response; immunoregulation; lung; lung lavage; metagenomics; microbial community; Moraxella; Neisseria; neutrophilia; nonhuman; obesity; polymerase chain reaction; Prevotella; Proteobacteria; respiratory tract allergy; Review; Streptococcus; Veillonella
