Περίληψη:
Objectives Previously published studies on parental occupational exposure to extremely low-frequency magnetic fields (ELF-MF) and risk of acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML) in their offspring were inconsistent. We therefore evaluated this question within the Childhood Leukemia International Consortium. Methods We pooled 11 case-control studies including 9723 childhood leukaemia cases and 17 099 controls. Parental occupational ELF-MF exposure was estimated by linking jobs to an ELF-MF job-exposure matrix (JEM). Logistic regression models were used to estimate ORs and 95% CIs in pooled analyses and meta-analyses. Results ORs from pooled analyses for paternal ELF-MF exposure >0.2 microtesla (μT) at conception were 1.04 (95% CI 0.95 to 1.13) for ALL and 1.06 (95% CI 0.87 to 1.29) for AML, compared with ≤0.2 μT. Corresponding ORs for maternal ELF-MF exposure during pregnancy were 1.00 (95% CI 0.89 to 1.12) for ALL and 0.85 (95% CI 0.61 to 1.16) for AML. No trends of increasing ORs with increasing exposure level were evident. Furthermore, no associations were observed in the meta-analyses. Conclusions In this large international dataset applying a comprehensive quantitative JEM, we did not find any associations between parental occupational ELF-MF exposure and childhood leukaemia. © © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Συγγραφείς:
Talibov, M.
Olsson, A.
Bailey, H.
Erdmann, F.
Metayer, C.
Magnani, C.
Petridou, E.
Auvinen, A.
Spector, L.
Clavel, J.
Roman, E.
Dockerty, J.
Nikkilä, A.
Lohi, O.
Kang, A.
Psaltopoulou, T.
Miligi, L.
Vila, J.
Cardis, E.
Schüz, J.
Λέξεις-κλειδιά:
acute lymphoblastic leukemia; acute myeloid leukemia; adolescent; Article; cancer risk; case control study; child; childhood leukemia; conception; controlled study; environmental exposure; female; human; magnetic field; major clinical study; male; maternal exposure; occupational exposure; occupational hazard; paternal exposure; pregnancy; preschool child; priority journal; progeny; acute lymphoblastic leukemia; acute myeloid leukemia; adverse event; infant; magnetic field; maternal exposure; meta analysis; occupational exposure; paternal exposure; prenatal exposure, Adolescent; Case-Control Studies; Child; Child, Preschool; Female; Humans; Infant; Leukemia, Myeloid, Acute; Magnetic Fields; Male; Maternal Exposure; Occupational Exposure; Paternal Exposure; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pregnancy; Prenatal Exposure Delayed Effects
