Περίληψη:
Background: There is a lack of prospective data on the potential association of Fusobacterium nucleatum (F. nucleatum) and colorectal cancer risk. In this study, we assessed whether antibody responses to F. nucleatum are associated with colorectal cancer risk in prediagnostic serum samples in the European Prospective Investigation into Nutrition and Cancer (EPIC) cohort. Methods: We applied a multiplex serology assay to simultaneously measure antibody responses to 11 F. nucleatum antigens in prediagnostic serum samples from 485 colorectal cancer cases and 485 matched controls. Conditional logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CI). Results: We observed neither a statistically significant colorectal cancer risk association for antibodies to individual F. nucleatum proteins nor for combined positivity to any of the 11 proteins (OR, 0.81; 95% CI, 0.62–1.06). Conclusions: Antibody responses to F. nucleatum proteins in prediagnostic serum samples from a subset of colorectal cancer cases and matched controls within the EPIC study were not associated with colorectal cancer risk. Impact: Our findings in prospectively ascertained serum samples contradict the existing literature on the association of F. nucleatum with colorectal cancer risk. Future prospective studies, specifically detecting F. nucleatum in stool or tissue biopsies, are needed to complement our findings. © 2019 American Association for Cancer Research.
Συγγραφείς:
Butt, J.
Jenab, M.
Pawlita, M.
Overvad, K.
Tjonneland, A.
Olsen, A.
Boutron-Ruault, M.-C.
Carbonnel, F.
Mancini, F.R.
Kaaks, R.
Kuhn, T.
Boeing, H.
Trichopoulou, A.
Karakatsani, A.
Palli, D.
Pala, V.M.
Tumino, R.
Sacerdote, C.
Panico, S.
Bueno-De-Mesquita, B.
Van Gils, C.H.
Vermeulen, R.C.H.
Weiderpass, E.
Quiros, J.R.
Duell, E.J.
Sanchez, M.-J.
Dorronsoro, M.
Huerta, J.M.
Ardanaz, E.
Van Guelpen, B.
Harlid, S.
Perez-Cornago, A.
Gunter, M.J.
Murphy, N.
Freisling, H.
Aune, D.
Waterboer, T.
Hughes, D.J.
Λέξεις-κλειδιά:
adhesin; bacterial protein; Fusobacterium nucleatum protein; outer membrane protein; porin; unclassified drug, antibody response; antigen specificity; Article; blood analysis; blood sampling; cancer diagnosis; cancer risk; child; clinical assessment; cohort analysis; colorectal cancer; controlled study; disease association; female; Fusobacterium; Fusobacterium nucleatum; human; infant; major clinical study; male; patient risk; priority journal; risk assessment; risk factor; serology; seroprevalence; blood; colorectal tumor; Fusobacterium nucleatum; pathogenicity; pathology; prospective study; virology, Colorectal Neoplasms; Female; Fusobacterium nucleatum; Humans; Prospective Studies
