Τίτλος:
Vinflunine in the treatment of relapsed metastatic urothelial cancer: A systematic review and meta-analysis of real-world series
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Vinflunine (VFL) is approved in Europe as second-line treatment of metastatic urothelial cancer after failure of platinum-containing therapy. We performed a systematic review and meta-analysis of real-world data (RWD) to assess utilization, efficacy and safety of VFL. Methods: We performed a MEDLINE search for the period of 1/1/2000-31/8/2017. Full-length articles providing post-marketing RWD on VFL in patients failing previous chemotherapy were eligible. Interventional clinical trials were excluded. Results: Ten studies with 797 patients were identified. According to pooled REs analysis, overall response rate was 19%, most frequent, all-grade toxicities were fatigue (41%), constipation (39%), nausea/vomiting (25%), and most prevalent Grade 3–4 toxicities were neutropenia (13%), anaemia (9%), fatigue (8%). Median OS was comparable to results reported in recent randomized studies. Conclusion: Our findings confirm the efficacy and safety of VFL in an unselected population and support the use of VFL in the changing treatment paradigm of relapsed mUC. © 2019 Elsevier B.V.
Συγγραφείς:
Bamias, A.
Hegele, A.
Medioni, J.
Castellano, D.
Doni, L.
Passalacqua, R.
Zagouri, F.
Tzannis, K.
Hussain, S.
Ullen, A.
Περιοδικό:
Critical Reviews in Oncology/Hematology
Εκδότης:
Elsevier Ireland Ltd
Λέξεις-κλειδιά:
vinflunine; antineoplastic agent; platinum derivative; vinblastine; vinflunine, anemia; asthenia; cancer prognosis; cancer recurrence; constipation; drug efficacy; drug response; drug safety; drug utilization; fatigue; fever; human; meta analysis; metastasis; nausea and vomiting; neutropenia; overall survival; progression free survival; Review; systematic review; thrombocytopenia; transitional cell carcinoma; aged; constipation; Europe; fatigue; female; male; metastasis; middle aged; nausea; pathology; recurrent disease; treatment outcome; urinary tract tumor; vomiting, Aged; Antineoplastic Combined Chemotherapy Protocols; Constipation; Europe; Fatigue; Female; Humans; Male; Middle Aged; Nausea; Neoplasm Metastasis; Platinum Compounds; Recurrence; Treatment Outcome; Urologic Neoplasms; Vinblastine; Vomiting
DOI:
10.1016/j.critrevonc.2019.05.006
