Περίληψη:
Objective:To investigate the associations between head and neck cancer (HNC) risk and occupations.Methods:We harmonized data on occupations in a pooled analysis of 8839 HNC cases and 13,730 controls in International Head and Neck Cancer Epidemiology (INHANCE) consortium. Logistic regression was used to estimate odds ratios (ORs) for associations of occupations and HNC risk. Population attributable fraction (PAF) for occupations was calculated using the formula PEC×(OR-1)/OR.1Results:Trend of increasing HNC risk was found with increasing duration of employment for many occupations, including cooks (OR=1.36; 95% confidence interval [CI] 1.09 to 1.68), cleaners (OR=1.38; 95% CI 1.13 to 1.69), painters (OR=1.82; 95% CI 1.42 to 2.35). The PAF for a priori occupations was 14.5% (95% CI 7.1% to 21.9%) for HNC.Conclusions:We found associations between certain occupations and HNC risks, including for subsites, with a duration-response relationship. Copyright © 2019 American College of Occupational and Environmental Medicine.
Συγγραφείς:
Khetan, P.
Boffetta, P.
Luce, D.
Stucker, I.
Curado, M.P.
Menezes, A.
Wunsch-Filho, V.
Ahrens, W.
Lagiou, P.
Serraino, D.
Richiardi, L.
Kjaerheim, K.
Conway, D.
Thomson, P.
Muscat, J.
Mates, D.
Ramroth, H.
Menvielle, G.
Vaughan, T.L.
Brenner, H.
Lee, Y.-C.A.
La Vecchia, C.
Hashibe, M.
Hashim, D.
Λέξεις-κλειδιά:
Article; cancer risk; carpenter; case control study; construction worker; controlled study; drinking behavior; driver; employment; head and neck squamous cell carcinoma; human; occupation; operator; painter; risk assessment; smoking; worker; Europe; factual database; head and neck tumor; North America; occupational disease; risk factor; South and Central America; statistical model, Databases, Factual; Europe; Head and Neck Neoplasms; Humans; Latin America; Logistic Models; North America; Occupational Diseases; Risk Factors
