Περίληψη:
Background: Hemangiopericytoma and solitary fibrous tumor (HPC/SFT) are considered to be one category according to the WHO 2016 classification of central nervous system tumors. HPC/SFT are subdivided into infantile (congenital) and adult type. Both are extremely rare entities, with little knowledge about etiology, prognosis, and optimal therapeutic strategy. Case Description: A 10-day-old girl was referred to our neurosurgical department due to hypotonia, palsy of the right oculomotor nerve, and prominent frontal fontanel. Imaging studies revealed a large occupying mass in the right middle cerebral fossa and the suprasellar cisterns. Only a subtotal resection of the tumor was possible, and postoperatively, she underwent chemotherapy (CHx). After a 3-year follow-up, the girl has minimum neurologic signs and receives no medications, and she can walk when she is supported. Conclusion: Congenital HPC/SFT is considered to have a benign behavior with a good prognosis. Treatment with gross total resection, when it is feasible, is the key to a good prognosis and low rates of recurrence. However, there is no consensus on the therapeutic strategy of a HPC/SFT, which is difficult to be completely resected. Literature lacks a therapeutic algorithm for these tumors, and thus, more clinical studies are needed to reach a consensus. ©2019 Published by Scientific Scholar on behalf of Surgical Neurology International.
Συγγραφείς:
Giakoumettis, D.
Nikas, I.
Stefanaki, K.
Kattamis, A.
Sfakianos, G.
Themistocleous, M.S.
Λέξεις-κλειδιά:
brain derived neurotrophic factor receptor; cyclophosphamide; dactinomycin; transcription factor Ets; vincristine, anterior fontanel; apoptosis; bleeding tendency; brain ventricle peritoneum shunt; cancer combination chemotherapy; case report; cavernous sinus; cell density; child; clinical article; computer assisted tomography; congenital tumor; craniotomy; echography; female; follow up; frontal lobe; giant intracranial congenital hemangiopericytoma; giant intracranial congenital hemangiopericytoma; head circumference; hemangiopericytoma; histopathology; human; intracranial tumor; jaundice; medical history; meninx; microsurgery; middle cranial fossa; mitosis rate; multiple cycle treatment; muscle hypotonia; muscle tone; neonatal intensive care unit; nerve paralysis; neuroimaging; neurologic disease; neurosurgery; nuclear magnetic resonance imaging; obstructive hydrocephalus; ophthalmoplegia; parietal lobe; patient referral; posterior fossa; postoperative care; postoperative period; priority journal; reverse transcription polymerase chain reaction; Review; school child; solitary fibrous tumor; staining; temporal lobe
