Τίτλος:
Contribution of ghrelin to functional gastrointestinal disorders’ pathogenesis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Functional gastrointestinal disorders (FGID) are heterogeneous disorders with a variety of clinical manifestations, primarily defined by signs and symptoms rather than a definite underlying cause. Their pathophysiology remains obscure and, although it is expected to differ according to the specific FGID, disruptions in the brain-gut axis are now thought to be a common denominator in their pathogenesis. The hormone ghrelin is an important component of this axis, exerting a wide repertoire of physiological actions, including regulation of gastrointestinal motility and protection of mucosal tissue. Ghrelin’s gene shows genetic polymorphism, while its protein product undergoes complex regulation and metabolism in the human body. Numerous studies have studied ghrelin’s relation to the emergence of FGIDs, its potential value as an index of disease severity and as a predictive marker for symptom relief during attempted treatment. Despite the mixed results currently available in scientific literature, the plethora of statistically significant findings shows that disruptions in ghrelin genetics and expression are plausibly related to FGID pathogenesis. The aim of this paper is to review current literature studying these associations, in an effort to uncover certain patterns of alterations in both genetics and expression, which could delineate its true contribution to FGID emergence, either as a causative agent or as a pathogenetic intermediate. ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Συγγραφείς:
Koutouratsas, T.
Kalli, T.
Karamanolis, G.
Gazouli, M.
Περιοδικό:
World Journal of Gastroenterology
Εκδότης:
Baishideng Publishing Group Co
Λέξεις-κλειδιά:
ghrelin; relamorelin; rikkunshito; ghrelin; growth hormone releasing factor, allele; biochemistry; cyclic vomiting syndrome; digestive system function disorder; dyspepsia; gene expression; genotype; GHRL gene; human; infantile colic; irritable colon; pathogenesis; pathophysiology; physiology; Review; single nucleotide polymorphism; systematic review; esophagus mucosa; gastrointestinal disease; gastrointestinal motility; genetics; hypophysis; intestine mucosa; metabolism; pathology; stomach mucosa, Esophageal Mucosa; Gastric Mucosa; Gastrointestinal Diseases; Gastrointestinal Motility; Ghrelin; Growth Hormone-Releasing Hormone; Humans; Intestinal Mucosa; Pituitary Gland
DOI:
10.3748/wjg.v25.i5.539
