Τίτλος:
Combined pulmonary fibrosis and emphysema characteristics in a Greek cohort
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Combined pulmonary fibrosis and emphysema (CPFE) has recently received great attention, with studies suggesting that it presents a distinct clinical entity while others have challenged this hypothesis. This nationwide study aimed to describe a large cohort of Greek CPFE patients and to examine potential prognostic factors for survival. Methods: This retrospective study included 97 patients with CPFE. Demographic and clinical data, pulmonary function tests, echocardiography results and bronchoalveolar lavage analysis were recorded. Results: Most patients were male (94.8%) and 92% were current or ex-smokers. Spirometry results were abnormal (forced vital capacity (FVC) 72.9±19.9% pred and forced expiratory volume in 1 s/FVC 82.9±9.7%) with reduced diffusing capacity of the lung for carbon monoxide (DLCO) (42.3±17.4% pred). Mean systolic pulmonary arterial pressure was 41.9±19.7 mmHg and pulmonary hypertension was present in 58.8% of patients. Mean 6-min walk distance was 335.4±159.4 m. Mean emphysema score was 14.23±8.69% and mean interstitial lung disease (ILD) extent was 39.58±19.82%. Mean survival was 84 months (95% CI 72-96 months). Patients with DLCO ≥39% pred had better survival than patients with DLCO <39% pred (p=0.031). Patients with ILD extent ≥30% had worse survival than patients with ILD extent <30% (p=0.037). Conclusions: Our results indicate that CPFE patients have preserved lung volumes associated with disproportionately reduced DLCO, while reduced DLCO and increased ILD extent was associated with worse prognosis. © ERS 2019.
Συγγραφείς:
Malli, F.
Papakosta, D.
Antoniou, K.
Dimadi, M.
Polychronopoulos, V.
Malagari, K.
Oikonomou, A.
Bouros, D.E.
Daniil, Z.
Περιοδικό:
ERJ Open Research
Εκδότης:
European Respiratory Society
Λέξεις-κλειδιά:
adult; Article; cohort analysis; disease severity; Doppler echocardiography; emphysema; female; forced expiratory volume; forced vital capacity; human; lung fibrosis; lung function test; lung lavage; major clinical study; male; middle aged; mortality; multicenter study; overall survival; pulmonary hypertension; retrospective study; six minute walk test; spirometry; systolic blood pressure
DOI:
10.1183/23120541.00014-2018
