Τίτλος:
Reproductive Factors, Exogenous Hormone Use, and Risk of B-Cell Non-Hodgkin Lymphoma in a Cohort of Women from the European Prospective Investigation into Cancer and Nutrition
Περίληψη:
The role of hormonal factors in the etiology of lymphoid neoplasms remains unclear. Previous studies have yielded conflicting results, have lacked sufficient statistical power to assess many lymphoma subtypes, or have lacked detailed information on relevant exposures. Within the European Prospective Investigation Into Cancer and Nutrition cohort, we analyzed comprehensive data on reproductive factors and exogenous hormone use collected at baseline (1992-2000) among 343,458 women, including data on 1,427 incident cases of B-cell non-Hodgkin lymphoma (NHL) and its major subtypes identified after a mean follow-up period of 14 years (through 2015). We estimated hazard ratios and 95% confidence intervals using multivariable proportional hazards modeling. Overall, we observed no statistically significant associations between parity, age at first birth, breastfeeding, oral contraceptive use, or ever use of postmenopausal hormone therapy and risk of B-cell NHL or its subtypes. Women who had undergone surgical menopause had a 51% higher risk of B-cell NHL (based on 67 cases) than women with natural menopause (hazard ratio = 1.51, 95% confidence interval: 1.17, 1.94). Given that this result may have been due to chance, our results provide little support for the hypothesis that sex hormones play a role in lymphomagenesis. © The Author(s) 2018.
Συγγραφείς:
Costas, L.
Lujan-Barroso, L.
Benavente, Y.
Allen, N.E.
Amiano, P.
Ardanaz, E.
Besson, C.
Boeing, H.
Bueno-De-Mesquita, B.
Cervenka, I.
Fortner, R.T.
Fournier, A.
Gunter, M.
Harlid, S.
Huerta, J.M.
Jerkeman, M.
Jirström, K.
Kaaks, R.
Karakatsani, A.
Khaw, K.-T.
Kotanidou, A.
Lund, E.
Masala, G.
Mattiello, A.
Melin, B.
Menéndez, V.
Murphy, N.
Nieters, A.
Overvad, K.
Riboli, E.
Sacerdote, C.
Sánchez, M.-J.
Schmidt, J.A.
Sieri, S.
Tjønneland, A.
Trichopoulou, A.
Tumino, R.
Vermeulen, R.
Weiderpass, E.
De Sanjosé, S.
Agudo, A.
Casabonne, D.
Λέξεις-κλειδιά:
age structure; baseline conditions; cancer; cell; cohort analysis; etiology; health risk; medicine; nutritional status; reproductive biology; sex hormone; womens health, adult; Article; B cell lymphoma; breast feeding; cancer incidence; cancer risk; childbirth; cohort analysis; disease association; female; follow up; groups by age; high risk population; hormonal therapy; human; middle aged; nonhodgkin lymphoma; oral contraceptive use; parity; postmenopause; reproduction; young adult; B cell lymphoma; clinical trial; estrogen therapy; Europe; multicenter study; proportional hazards model; prospective study; reproductive history; risk factor; women's health, Europe, Breast Feeding; Estrogen Replacement Therapy; Europe; Female; Humans; Lymphoma, B-Cell; Proportional Hazards Models; Prospective Studies; Reproductive History; Risk Factors; Women's Health
