Τίτλος:
Evaluation of pre-mir-34a rs72631823 single nucleotide polymorphism in triple negative breast cancer: A case-control study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Aim: The purpose of this study is to evaluate the role of pre-miR34a rs72631823 as potential risk factor and/or prognostic marker in patients with triple negative breast cancer. Methods: 114 samples of DNA from paraffin embedded breast normal tissues of patients with triple negative breast cancer and 124 samples of healthy controls were collected and analyzed for pre-miR34a rs72631823 polymorphism. Results: Pre-miR34a rs72631823 A allele was associated with increased TNBC risk both in univariate and multivariate analysis. The number of pre-miR34a rs72631823 AA subjects was very small and the association did not reach significance (p = 0.176, Fisher's exact test). The examined polymorphism was not associated with overall survival at the univariate or multivariate Cox regression analysis (adjusted HR = 1.60, 95%CI: 0.64-3.96 for miR34 rs72631823 GA/AA vs. GG). Conclusion: Our case-control study suggests that pre-miR34a rs72631823 A allele is associated with increased triple negative breast cancer risk. © 2018 Kalapanida et al.
Συγγραφείς:
Kalapanida, D.
Zagouri, F.
Gazouli, M.
Zografos, E.
Dimitrakakis, C.
Marinopoulos, S.
Giannos, A.
Sergentanis, T.N.
Kastritis, E.
Terpos, E.
Dimopoulos, M.-A.
Περιοδικό:
OncoTargets and therapy
Εκδότης:
Impact Journals, LLC
Λέξεις-κλειδιά:
microRNA 34a, adult; alcohol consumption; Article; cancer grading; cancer prognosis; cancer risk; cancer staging; cancer survival; cancer tissue; case control study; controlled study; educational status; female; follow up; gene frequency; human; human tissue; major clinical study; menarche; menopause; middle aged; overall survival; prospective study; risk factor; single nucleotide polymorphism; smoking; survival rate; triple negative breast cancer
DOI:
10.18632/oncotarget.26385
