Τίτλος:
The Role of Angiogenesis Inhibitors in Hypertension: Following "ariadne's Thread"
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Arterial hypertension (HT) is one of the most frequently recorded comorbidities among patients under antiangiogenic therapy. Inhibitors of vascular endothelial growth factor and vascular endothelial growth factor receptors are most commonly involved in new onset or exacerbation of pre-existing controlled HT. From the pathophysiology point of view, data support that reduced nitric oxide release and sodium and fluid retention, microvascular rarefaction, elevated vasoconstrictor levels, and globular injury might contribute to HT. The purpose of this review was to present recent evidence regarding the incidence of HT induced by antiangiogenic agents, to analyze the pathophysiological mechanisms, and to summarize current recommendations for the management of elevated blood pressure in this field. © 2018 American Journal of Hypertension, Ltd. All rights reserved.
Συγγραφείς:
Sanidas, E.
Papadopoulos, D.P.
Velliou, M.
Tsioufis, K.
Mantzourani, M.
Iliopoulos, D.
Perrea, D.
Barbetseas, J.
Papademetriou, V.
Περιοδικό:
American Journal of Hypertension
Εκδότης:
Oxford University Press
Λέξεις-κλειδιά:
angiogenesis inhibitor; antihypertensive agent; protein kinase inhibitor, animal; arterial pressure; drug effect; human; hypertension; pathophysiology; risk factor; risk reduction; treatment outcome, Angiogenesis Inhibitors; Animals; Antihypertensive Agents; Arterial Pressure; Humans; Hypertension; Protein Kinase Inhibitors; Risk Factors; Risk Reduction Behavior; Treatment Outcome
