Περίληψη:
Statins are the most common drugs administered for patients with cardiovascular disease. However, due to statin-associated muscle symptoms, adherence to statin therapy is challenging in clinical practice. Certain nutraceuticals, such as red yeast rice, bergamot, berberine, artichoke, soluble fiber, and plant sterols and stanols alone or in combination with each other, as well as with ezetimibe, might be considered as an alternative or add-on therapy to statins, although there is still insufficient evidence available with respect to long-term safety and effectiveness on cardiovascular disease prevention and treatment. These nutraceuticals could exert significant lipid-lowering activity and might present multiple non–lipid-lowering actions, including improvement of endothelial dysfunction and arterial stiffness, as well as anti-inflammatory and antioxidative properties. The aim of this expert opinion paper is to provide the first attempt at recommendation on the management of statin intolerance through the use of nutraceuticals with particular attention on those with effective low-density lipoprotein cholesterol reduction. © 2018 American College of Cardiology Foundation
Συγγραφείς:
Banach, M.
Patti, A.M.
Giglio, R.V.
Cicero, A.F.G.
Atanasov, A.G.
Bajraktari, G.
Bruckert, E.
Descamps, O.
Djuric, D.M.
Ezhov, M.
Fras, Z.
von Haehling, S.
Katsiki, N.
Langlois, M.
Latkovskis, G.
Mancini, G.B.J.
Mikhailidis, D.P.
Mitchenko, O.
Moriarty, P.M.
Muntner, P.
Nikolic, D.
Panagiotakos, D.B.
Paragh, G.
Paulweber, B.
Pella, D.
Pitsavos, C.
Reiner, Ž.
Rosano, G.M.C.
Rosenson, R.S.
Rysz, J.
Sahebkar, A.
Serban, M.-C.
Vinereanu, D.
Vrablík, M.
Watts, G.F.
Wong, N.D.
Rizzo, M.
International Lipid Expert Panel (ILEP)
Λέξεις-κλειδιά:
berberine; bergamot oil; C reactive protein; hydroxymethylglutaryl coenzyme A reductase inhibitor; isoflavone derivative; low density lipoprotein cholesterol; nutraceutical; phytosterol; soluble fiber; unclassified drug; hydroxymethylglutaryl coenzyme A reductase inhibitor, artichoke; cardiovascular disease; cardiovascular risk; clinical effectiveness; drug hypersensitivity; garlic; human; lipid metabolism; low density lipoprotein cholesterol level; lupin; priority journal; pulse wave; Review; tea; clinical study; diet therapy; dietary supplement; dyslipidemia, Clinical Studies as Topic; Dietary Supplements; Dyslipidemias; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors
