Τίτλος:
Beneficial effect of synbiotics on experimental colon cancer in rats
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background/Aims: The aim of this study was to investigate the influence of a synbiotic preparation (a mixture of six probiotics and a prebiotic) on aberrant crypt foci (ACF) formation, dysplasia, inflammation, and colitis-like lesions in experimental colon cancer in rats. Materials and Methods: Sixty male rats were categorized into three groups of 20 animals each. Group A was administered 1,2-dimethylydrazine, 15 mg/kg body weight (BW), once a week for 2 weeks. Group B was administered 1,2-dimethylydrazine at the same dose plus synbiotic, started after the second dose of carcinogen and lasted for 5 weeks. Group C was administered synbiotic plus carcinogen from the beginning of the experiment and lasted for 7 weeks. Animals were killed at the end of week 7. Results: At the end of the experiment, the animals that received carcinogen plus the synbiotic had 100%, whereas the animals that received only carcinogen has 70% survival. Animals of groups B and C had significantly lower percentage of inflammation, colitis-like lesions, and ACF dysplasia than animals of group A, whereas those of group C had the least pathological lesions. Conclusion: Synbiotics seem to protect against the appearance of preneoplastic colon lesions in rats. The results of this experimental study suggest that treatment with a synbiotic preparation exerts significant antimutagenic properties against the development of preneoplastic lesions in rats. © Copyright 2018.
Συγγραφείς:
Gavresea, F.
Vagianos, C.
Korontzi, M.
Sotiropoulou, G.
Dadioti, P.
Triantafillidis, J.K.
Papalois, A.E.
Περιοδικό:
Turkish Journal of Gastroenterology
Εκδότης:
AVES İbrahim KARA
Λέξεις-κλειδιά:
1,2 dimethylhydrazine; carcinogen; synbiotic agent; antineoplastic agent; synbiotic agent, aberrant crypt focus; adult; animal experiment; animal model; animal tissue; Article; Bifidobacterium; Bifidobacterium longum; cancer survival; colitis; colon cancer; controlled study; drug effect; gastrointestinal dysplasia; inflammation; Lactobacillus acidophilus; Lactobacillus casei; Lactobacillus delbrueckii subsp. bulgaricus; male; nonhuman; rat; Streptococcus thermophilus; animal; chemically induced; colon; colon tumor; microbiology; precancer, 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Carcinogens; Colon; Colonic Neoplasms; Male; Precancerous Conditions; Rats; Synbiotics
DOI:
10.5152/tjg.2018.17469
