Τίτλος:
Inflammation associates with impaired small arterial elasticity early in HIV disease
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
We estimated small arterial elasticity and used linear regression to evaluate its association with inflammatory biomarkers among antiretroviral therapy-naïve, HIV-positive patients with high CD4+ counts. After adjustment, high-sensitivity C-reactive protein and interleukin-6 were inversely associated with small arterial elasticity. These data suggest that systemic inflammation may contribute to vascular dysfunction even in very early HIV disease. © The Author(s) 2018.
Συγγραφείς:
Peterson, T.E.
Hullsiek, K.H.
Engen, N.W.
Kumarasamy, N.
Lebech, A.-M.
Liappis, A.
Papadopoulos, A.
Polizzotto, M.N.
Schreiner, P.J.
Duprez, D.
Baker, J.V.
INSIGHT START (Strategic Timing of AntiRetroviral Treatment) Study Group
Περιοδικό:
Open Forum Infectious Diseases
Εκδότης:
Oxford University Press
Λέξεις-κλειδιά:
adiponectin; biological marker; C reactive protein; cholesterol; hemoglobin A1c; high density lipoprotein cholesterol; intercellular adhesion molecule 1; interleukin 27; interleukin 6; interleukin 8; low density lipoprotein cholesterol; serum amyloid A; triacylglycerol; tumor necrosis factor, adult; antiinflammatory activity; antiretroviral therapy; arterial pressure; Article; body mass; CD4 lymphocyte count; clinical trial (topic); cross-sectional study; elasticity; enzyme linked immunosorbent assay; fluorescence analysis; Hospital Anxiety and Depression Scale; human; Human immunodeficiency virus infection; hypertension; inflammation; major clinical study; male; physical activity; priority journal; radial artery; tonometry; virus load
