Τίτλος:
Survivin expression as an independent predictor of overall survival in pancreatic adenocarcinoma
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Context: Survivin is an antiapoptotic protein with a role in tumorigenesis and suggested prognostic value in several proliferative diseases. Aims: This study aimed to examine the role of survivin as a prognostic marker in pancreatic adenocarcinoma (PDAC). Settings and Design: Fifty-one specimens of PDAC were assessed for survivin expression by immunohistochemistry. Subjects and Methods: Overall survival and 1-, 3-, and 5-year survival were retrieved retrospectively. Statistical Analysis Used: Bivariate analysis was conducted using Chi-square and Mann-Whitney U tests, while survival analysis was conducted using Kaplan-Meier statistics. Results: Of the 51 assessed cases, 49% were positive for survivin. Survivin expression was significantly correlated 1-year survival and overall survival, particularly in bcl-2 positive cases. Conclusions: Survivin may be implicated in the bcl-2 and p53 pathways and therefore in the biology of PDAC. Its potential use as a survival predictor and therapeutic target represent a promising field. © 2016 Journal of Cancer Research and Therapeutics | Published by Wolters Kluwer - Medknow.
Συγγραφείς:
Contis, J.
Lykoudis, P.M.
Goula, K.
Karandrea, D.
Kondi-Pafiti, A.
Περιοδικό:
Journal of Cancer Research and Therapeutics
Εκδότης:
Wolters Kluwer--Medknow Publications
Λέξεις-κλειδιά:
epidermal growth factor receptor; protein bcl 2; protein p53; survivin; tumor marker; BCL2 protein, human; BIRC5 protein, human; inhibitor of apoptosis protein; protein bcl 2; protein p53; TP53 protein, human; tumor marker; tumor protein, adult; aged; Article; cancer grading; cancer prognosis; cancer survival; female; human; human tissue; immunohistochemistry; major clinical study; male; overall survival; pancreas adenocarcinoma; protein expression; retrospective study; survival analysis; survival prediction; adenocarcinoma; apoptosis; disease free survival; genetics; Kaplan Meier method; middle aged; pancreas tumor; pathology; prognosis, Adenocarcinoma; Adult; Aged; Apoptosis; Biomarkers, Tumor; Disease-Free Survival; Female; Humans; Immunohistochemistry; Inhibitor of Apoptosis Proteins; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Proteins; Pancreatic Neoplasms; Prognosis; Proto-Oncogene Proteins c-bcl-2; Tumor Suppressor Protein p53
DOI:
10.4103/0973-1482.187346
