Τίτλος:
IGF and IGFBP as an index for discrimination between Vitamin D supplementation responders and nonresponders in overweight Saudi subjects
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Vitamin D deficiency is common in the Kingdom of Saudi Arabia (KSA). Therefore, it is significant to recognize which biochemical markers modulate serum 25 hydroxyvitamin D (25(OH)D) in response to vitamin D supplementation in such a population. Our aim was to study the correlation of insulin-like growth factor (IGF) and insulin growth factor binding protein (IGFBP) with serum 25(OH)D in response to vitamin D supplementation in a Saudi population. A total of 199 (89 males/110 females) vitamin D deficient subjects (25 (OH)D level <50 nmol/L), aged 40.4 ± 11.4 years, were given vitamin D supplements (50,000 IU/mL every week) for the first 2 months, then twice a month for 2 months, followed by daily 1000 IU in the last 2 months. Fasting blood samples were taken at baseline and 6 months after the final dose of vitamin D. Serum 25(OH)D, IGF-1 and IGF-2, and IGFBPs 2-5 were measured. Vitamin D response was computed for all subjects as the difference in levels of serum 25(OH)D concentration at the end of 6 months compared to baseline. After intervention, serum 25(OH)D concentration significantly increased from 35.6 nmol/L (26.6-43.5) to 61.8 nmol/L (54.8-73.3) in responder subjects (P < .01) and from 35.1 nmol/L (21.2-58.2) to 38.3 nmol/L (25.5-48.3) in nonresponders (P = .13). Subjects with lower baseline serum IGF-II, IGFBP-2, and IGF-1/IGFBP-3 ratio are more sensitive to acute vitamin D status changes. IGF1 and IGF-1/IGFBP-3 ratio significantly increased in all subjects after 6 months (P = .01). Changes in 25(OH)D was significantly associated with changes in IGFBP-2 and IGF-1/IGFBP-3 ratio in responders only. This study proposes that changes in circulating IGF-I and IGFBP-3 are modulated by vitamin D supplementation and can be taken into consideration in investigations involving vitamin D correction. Moreover, increase in serum 25(OH)D and IGF-I/IGFBP-3 molar ratio are more sensitive markers for the response to vitamin D supplementation in Saudi population. © 2018 the Author(s). Published by Wolters Kluwer Health, Inc.
Συγγραφείς:
Al-Daghri, N.M.
Yakout, S.M.
Wani, K.
Khattak, M.N.K.
Garbis, S.D.
Chrousos, G.P.
Al-Attas, O.S.
Alokail, M.S.
Περιοδικό:
Medicine (United States)
Εκδότης:
Lippincott Williams and Wilkins
Λέξεις-κλειδιά:
25 hydroxyvitamin D; binding protein; colecalciferol; insulin growth factor binding protein; somatomedin; unclassified drug; vitad 50000; vitamin D; 25-hydroxyvitamin D; biological marker; colecalciferol; somatomedin binding protein; somatomedin C; vitamin D, adult; anthropometry; Article; biochemical analysis; blood sampling; female; follow up; human; major clinical study; male; obesity; priority journal; prospective study; Saudi; tablet; treatment duration; treatment response; vitamin blood level; vitamin D deficiency; vitamin supplementation; analogs and derivatives; blood; complication; dietary supplement; metabolism; obesity; Saudi Arabia; vitamin D deficiency, Adult; Biomarkers; Cholecalciferol; Dietary Supplements; Female; Humans; Insulin-Like Growth Factor Binding Proteins; Insulin-Like Growth Factor I; Male; Overweight; Prospective Studies; Saudi Arabia; Vitamin D; Vitamin D Deficiency
DOI:
10.1097/MD.0000000000010702
