Τίτλος:
Follow-up of the retinal nerve fiber layer thickness of diabetic patients type 2, as a predisposing factor for glaucoma compared to normal subjects
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Purpose: To evaluate and follow-up the retinal nerve fiber layer (RNFL) thickness in patients with diabetes mellitus type 2 compared to a group of healthy individuals with similar demographic characteristics. Patients and methods: This is a prospective, noninvasive, observational case series study. For the purposes of the study, 27 eyes of diabetic patients without diabetic retinopathy, 24 eyes of patients with mild retinopathy, and 25 normal age-matched subjects (control group [CG]) were examined. All participants underwent complete ophthalmological examination and imaging with GDx variable corneal compensation scanning laser polarimetry. Follow-up was 2 years for all three groups. Results: The mean inferior average was statistically significantly lower in both diabetic groups compared to CG at baseline examination and during follow-up. The nerve fiber indicator (NFI) was higher in both diabetic groups compared to CG, both at baseline examination and during follow-up. The NFI was 21.7±11.9 and 22.0±11.8 for the diabetic group without retinopathy, 20.8±9.6 and 21.9±9.8 for the group with mild retinopathy, and 15.3±5.4 and 15.9±5.5 for the normal subjects, at baseline and 24 months, respectively. There was no statistically significant reduction of the RNFL thickness in all three groups compared to baseline examination. Conclusion: This is the first long-term study documenting the RNFL thickness in diabetic patients in comparison with normal controls. Although the lower RNFL was found thinner in diabetics, the 2-year follow-up showed no significant reduction of RNFL thickness in all groups, indicating that RNFL damage may occur early in diabetic patients. © 2017 Takis et al.
Συγγραφείς:
Takis, A.
Alonistiotis, D.
Ioannou, N.
Kontou, E.
Mitsopoulou, M.
Papaconstantinou, D.
Περιοδικό:
Clinical Ophthalmology (Auckland, NZ)
Εκδότης:
Dove Medical Press Ltd
Λέξεις-κλειδιά:
hemoglobin A1c, adult; aged; Article; best corrected visual acuity; controlled study; diabetic patient; diabetic retinopathy; diagnostic imaging; disease duration; disease predisposition; disease severity; eye examination; female; glaucoma; glycemic control; human; intraocular pressure; laser coagulation; macular edema; major clinical study; male; non insulin dependent diabetes mellitus; non invasive procedure; observational study; open angle glaucoma; optic nerve disease; optical coherence tomography; prevalence; prospective study; retinal nerve fiber layer thickness; risk factor; scanning laser polarimetry; very elderly
DOI:
10.2147/OPTH.S129935
