Τίτλος:
Pulse wave velocity and cardiac autonomic function in type 2 diabetes mellitus
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Increased carotid-femoral pulse wave velocity (PWV) has been associated with incident cardiovascular disease, independently of traditional risk factors. Cardiac autonomic dysfunction is a common complication of diabetes and has been associated with reduced aortic distensibility. However, the association of cardiac autonomic dysfunction with PWV is not known. In this study we examined the association between cardiac autonomic function and PWV in subjects with type 2 diabetes mellitus. Methods: A total of 290 patients with type 2 diabetes were examined. PWV was measured at the carotid-femoral segment with applanation tonometry. Central mean arterial blood pressure (MBP) was determined by the same apparatus. Participants were classified as having normal (n = 193) or abnormal (n = 97) PWV values using age-corrected values. Cardiac autonomic nervous system activity was determined by measurement of parameters of heart rate variability (HRV). Results: Subjects with abnormal PWV were older, had higher arterial blood pressure and higher heart rate than those with normal PWV. Most of the values of HRV were significantly lower in subjects with abnormal than in those with normal PWV. Multivariate analysis, after controlling for various confounding factors, demonstrated that abnormal PWV was associated independently only with peripheral MBP [odds ratio (OR) 1.049, 95% confidence intervals (CI) 1.015-1.085, P = 0.005], central MBP (OR 1.052, 95% CI 1.016-1.088, P = 0.004), log total power (OR 0.490, 95% CI 0.258-0.932, P = 0.030) and log high frequency power (OR 0.546, 95% CI 0.301-0.991, P = 0.047). Conclusions: In subjects with type 2 diabetes, arterial blood pressure and impaired cardiac autonomic function is associated independently with abnormal PWV. © 2017 The Author(s).
Συγγραφείς:
Chorepsima, S.
Eleftheriadou, I.
Tentolouris, A.
Moyssakis, I.
Protogerou, A.
Kokkinos, A.
Sfikakis, P.P.
Tentolouris, N.
Περιοδικό:
BMC Endocrine Disorders
Εκδότης:
BioMed Central Ltd.
Λέξεις-κλειδιά:
insulin; oral antidiabetic agent; triacylglycerol, adult; applanation tonometry; arterial stiffness; Article; autonomic nervous system function; cardiac autonomic function; cardiac autonomic nervous system function; cardiovascular risk; comparative study; controlled study; diabetic patient; diastolic blood pressure; female; heart function; heart rate variability; human; major clinical study; male; mean arterial pressure; middle aged; non insulin dependent diabetes mellitus; peripheral neuropathy; pulse wave; risk assessment; systolic blood pressure; tonometry; aged; blood; blood pressure; cross-sectional study; heart rate; non insulin dependent diabetes mellitus; pathophysiology; physiology; pressoreceptor reflex; procedures; pulse wave, Aged; Baroreflex; Blood Pressure; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Heart Rate; Humans; Male; Middle Aged; Pulse Wave Analysis
DOI:
10.1186/s12902-017-0178-2
