Τίτλος:
Orchitis reveals an extragonadal primary mediastinal thymic seminoma: A coincidence or not?
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Mediastinal thymic seminomas are rare male germ cell tumors with extragonadal origin that appear predominately with a cystic appearance. Case presentation: A 22-year-old male was referred to our department for further investigation of a mediastinal mass discovered incidentally during routine chest X-ray. The patient has denied any symptoms including dyspnea, chest pain, cough, fever, dysphagia, hemoptysis, weight loss, and weakness. His past medical history was remarkable for orchitis, for which he had undergone a bilateral testicular biopsy, without the latter however, indicating the presence of a germ cell tumor or a premalignant lesion. Contrast-enhanced chest computed tomography revealed a lobulated and well-marginated cystic lesion in the anterior mediastinum. Differential diagnosis included mostly a multilocular thymic cyst, a lymphoma, a seminoma, or a soft tissue tumor. Resection of the mass revealed a primary thymic seminoma. Conclusions: A surgical approach for the management of these tumors might be reasonable considering that an extensive sampling is mandatory to gain an appropriate biopsy preoperatively in order to securely confirm or refute the presence of a mediastinal extragonadal tumor. Orchitis might be a sign of a general disorder of the germ cells which might transform in time. © 2017 The Author(s).
Συγγραφείς:
Tampakis, A.
Tampaki, E.C.
Damaskos, C.
Feretis, T.
Thymara, I.
Kontzoglou, K.
Tomos, P.
Kouraklis, G.
Περιοδικό:
World Journal of Surgical Oncology
Εκδότης:
BioMed Central Ltd.
Λέξεις-κλειδιά:
cisplatin; lactate dehydrogenase; membrane protein; monoclonal antibody D2-40; octamer transcription factor 4; organic cation transporter 3; protein PLAP; protein SALL4; stem cell factor receptor; unclassified drug, adult; Article; cancer surgery; case report; computer assisted tomography; contrast enhancement; coughing; differential diagnosis; dysphagia; dyspnea; excision; fever; hemoptysis; histopathology; human; human cell; human tissue; immunohistochemistry; lymphoma; male; mediastinal thymic seminoma; medical history; orchitis; seminoma; soft tissue tumor; testis biopsy; thorax pain; thorax radiography; thymus cyst; weakness; weight reduction; Mediastinal Neoplasms; orchitis; pathology; prognosis; seminoma; Thymus Neoplasms; young adult, Adult; Diagnosis, Differential; Humans; Male; Mediastinal Neoplasms; Orchitis; Prognosis; Seminoma; Thymus Neoplasms; Young Adult
DOI:
10.1186/s12957-017-1146-z
