Τίτλος:
The effect of the antioxidant drug U-74389G on urea levels during ischemia reperfusion injury in rats
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
This experimental study examined the effect of the antioxidant drug U-74389G, on a rat model and particularly in a renal ischemia- reperfusion protocol. The effects of that molecule were studied biochemically using blood mean urea levels. Forty rats of mean weight 231.875 g were used in the study. Urea levels were measured at 60 min of reperfusion (groups A and C) and at 120 min of reperfusion (groups B and D). The drug U-74389G was administered only in groups C and D. U-74389G administration significantly decreased the predicted urea levels by 11.35%±2.73% (P=0.0001). Reperfusion time non-significantly increased the predicted urea levels by 2.26%±3.29% (P=0.4103). However, U-74389G administration and reperfusion time together significantly decreased the predicted urea levels by 6.31%±1.70% (P=0.0005). U-74389G administration whether it interacted or not with reperfusion time had significant decreasing effect on the urea serum levels, reflecting a respective renal function augmentation. © Copyright C. ?sompos et al., 2017 Licensee PAGE Press.
Συγγραφείς:
Tsompos, C.
Panoulis, C.
Toutouzas, K.
Triantafyllou, A.
Zografos, G.
Papalois, A.
Περιοδικό:
Italian Journal of Medicine
Εκδότης:
Page Press Publications
Λέξεις-κλειδιά:
21 [4 [2,6 bis(1 pyrrolidinyl) 4 pyrimidinyl] 1 piperazinyl]pregna 1,4,9(11) triene 3,20 dione; acid phosphatase; alkaline phosphatase; calcium ion; chloride ion; creatine kinase; glucose; hemoglobin; magnesium ion; phosphate; protein; sodium ion; urea, acid phosphatase blood level; alkaline phosphatase blood level; animal experiment; antioxidant activity; Article; body mass; calcium blood level; chloride blood level; controlled study; creatine kinase blood level; erythrocyte count; female; glucose blood level; hematocrit; hemoglobin blood level; hemoglobin determination; leukocyte count; magnesium blood level; mean cell hemoglobin; mean cell hemoglobin concentration; nonhuman; phosphate blood level; platelet distribution width; protein blood level; rat; red blood cell distribution width; reperfusion injury; sodium blood level; thrombocyte count; urea blood level
DOI:
10.4081/itjm.2017.719
