Τίτλος:
The value of focally enhanced gastritis in the diagnosis of pediatric inflammatory bowel diseases
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background and aims: Focally enhanced gastritis (FEG) has been suggested as a diagnostic marker for patients with Crohn's disease. In this study we evaluated the prevalence of FEG in children with inflammatory bowel diseases (IBD) and assessed the ability of FEG to distinguish IBD from non-IBD patients. Methods: A retrospective study of the children who underwent esophagogastroduodenal endoscopy (EGD) during 2004-2011 was performed, after excluding individuals with H. pylori infection and celiac disease. Two groups were studied: patients with IBD (IBD group, n. = 185) and non-IBD patients who underwent endoscopy of the upper gastrointestinal tract for various abdominal complaints (non-IBD group, n. = 684). Relation of FEG to age and gender was also assessed. Results: FEG was found significantly more frequently among children with IBD (35.7% vs 3.4%, respectively, p. <. 0.001). Children with FEG were 15.4 times more likely to have IBD than to belong in the non-IBD group. All types of IBD had significantly higher frequencies of FEG compared to non-IBD individuals (Crohn's disease: 54.1%, ulcerative colitis: 21.6%, IBD unclassified: 18.4%, all three comparisons with the non-IBD group: p-values. <. 0.001). FEG positivity was more common in females compared to males with Crohn's disease and ulcerative colitis and in children younger than 2. years in the IBD-unspecified group. FEG achieved a sensitivity of 35.7% and specificity of 96.6% in distinguishing between IBD from non-IBD patients. Conclusions: FEG has significantly higher prevalence in children with IBD, particularly Crohn's disease and can be a valuable supporting finding in cases of indefinite diagnosis. © 2012 European Crohn's and Colitis Organisation.
Συγγραφείς:
Roka, K.
Roma, E.
Stefanaki, K.
Panayotou, I.
Kopsidas, G.
Chouliaras, G.
Περιοδικό:
Journal of Crohn's and Colitis
Λέξεις-κλειδιά:
age distribution; article; child; childhood disease; clinical evaluation; Crohn disease; esophagogastroduodenoscopy; female; focally enhanced gastritis; gastritis; gastrointestinal endoscopy; human; major clinical study; male; predictive value; preschool child; prevalence; priority journal; retrospective study; school child; sensitivity and specificity; sex difference; statistical significance; ulcerative colitis; upper gastrointestinal tract, CD; Crohn's disease; FEG; Focally enhanced gastritis; IBD; Inflammatory bowel disease; Inflammatory bowel disease unclassified; negative predictive value; NPV; positive predictive value; PPV; Prognostic factors; UC; Ulcerative colitis, Age Factors; Case-Control Studies; Child; Child, Preschool; Endoscopy, Gastrointestinal; Female; Gastritis; Humans; Infant; Inflammatory Bowel Diseases; Male; Prevalence; Retrospective Studies; Sensitivity and Specificity; Sex Factors
DOI:
10.1016/j.crohns.2012.11.003
