Τίτλος:
A cross sectional study of HPV type prevalence according to age and cytology
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: A cross sectional study to investigate HPV prevalence according to age and cytology.Methods: Women presenting to a gynaecological outpatient clinic for a Pap smear test were included in the study (n=3177). All women had cervical cytology and HPV testing.Results: Overall prevalence of any 24 HPV type analysed was 33.1% (95% CI 31.5% to 34.7%) and HPV 16 and HPV 42 were the most frequent (6.7% (95% CI 5.8% to 7.6%), 6.8% (95% CI 5.9% to 7.6%)), in total samples. Multiple HPV infection rate was 12.9% (95% CI 11.8% to 14.1%). High risk HPV (hrHPV) types were present in 27.4% (95% CI 25.8% to 28.9%) of the samples.HPV prevalence was highest among 14 to 19 y.o (46.6% (95% CI 40.7%-52.4%)) and second highest among 30-34 y.o. (39.7%, 95% CI 35.4%-44%). HPV 16 was highest among 20-24 (9.0% (95% CI 6.4%-11.6%)) and second highest among 50 to 54 y.o. (6.3% (95% CI 2.9% to 9.8%).In Low-grade Squamous Intraepithelial Lesions (LgSIL) cytology samples, the most frequently detected hrHPV types were: 16 (14.5% (95% CI 12.1% to 16.9%)), 51 (13.0% (95% CI 10.7% to 15.3%)) and 53 (9.1% (95% CI 7.2% to 11.1%)) and in High-grade Squamous Intraepithelial Lesions (HgSIL) were: HPV 16 (37.2% (95% CI 26.5% to 47.9%)), HPV 51 (17.9% (95% CI 9.4% to 26.5%)) and HPV 18 (12.8% (95% CI 5.4% to 20.2%)).Conclusions: In the population studied, HPV 16 and 51 were the most frequent detected hrHPV types. HPV positivity, hrHPV and multiple HPV types infections were higher in young women, while HPV prevalence declined with increasing age and presented two peaks a higher (14-19 y.o.) and a lower one (30-34 y.o.) These results may contribute to the creation of a national screening programme. © 2013 Argyri et al.; licensee BioMed Central Ltd.
Συγγραφείς:
Argyri, E.
Papaspyridakos, S.
Tsimplaki, E.
Michala, L.
Myriokefalitaki, E.
Papassideri, I.
Daskalopoulou, D.
Tsiaoussi, I.
Magiakos, G.
Panotopoulou, E.
Περιοδικό:
BMC Infectious Diseases
Λέξεις-κλειδιά:
adolescent; adult; age; aged; article; controlled study; cross-sectional study; female; high grade squamous intraepithelial lesion; high risk patient; human; Human papillomavirus type 16; Human papillomavirus type 18; Human papillomavirus type 42; low grade squamous intraepithelial lesion; major clinical study; nonhuman; outpatient department; Papanicolaou test; papillomavirus infection; prevalence; uterine cervix cytology; uterine cervix disease; virus detection; virus typing; age; classification; genetics; isolation and purification; middle aged; Papilloma virus; pathology; prevalence; uterine cervix; vagina smear; virology; virus infection, Adolescent; Adult; Age Factors; Aged; Cervix Uteri; Female; Humans; Middle Aged; Papillomaviridae; Papillomavirus Infections; Prevalence; Tumor Virus Infections; Vaginal Smears; Young Adult
DOI:
10.1186/1471-2334-13-53
