Τίτλος:
Granisetron versus tropisetron in the prevention of postoperative nausea and vomiting after total thyroidectomy
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Postoperative nausea and vomiting (PONV) are frequently encountered after thyroidectomy. For PONV prevention, selective serotonin 5-hydroxytryptamine type 3 (5-HT 3 ) receptor antagonists are considered one of the first-line therapy. We report on the efficiency of granisetron and tropisetron, with that of placebo on the prevention of PONV in patients undergoing total thyroidectomy. Methods: One hundred twenty-seven patients were divided into three groups and randomized to receive intravenously, prior to induction of anesthesia, tropisetron 5 mg, or granisetron 3 mg, or normal saline. All patients received additionally 0.625 mg droperidol. All episodes of postoperative PONV during the first 24 h after surgery were evaluated. Results: Nausea visual analogue scale (VAS) score was lower in tropisetron and granisetron groups than the control group at all measurements ( P<0.01) except for the 8-h measurement for tropisetron ( P=0.075). Moreover, granisetron performed better than tropisetron ( P<0.011 at 4 h and P<0.01 at all other points of time) apart from the 2-h measurement. Vomiting occurred in 22.2%, 27.5%, and 37.5% in granisetron, tropisetron, and control groups, respectively ( P=0.43). Conclusions: The combination of the 5-HT 3 antagonists with droperidol given before induction of anesthesia is well tolerated and superior to droperidol alone in preventing nausea but not vomiting after total thyroidectomy.
Συγγραφείς:
Papadima, A.
Gourgiotis, S.
Lagoudianakis, E.
Pappas, A.
Seretis, C.
Antonakis, P.T.
Markogiannakis, H.
Makri, I.
Manouras, A.
Περιοδικό:
Saudi Journal of Anaesthesia
Λέξεις-κλειδιά:
droperidol; granisetron; placebo; sodium chloride; tropisetron, adult; aged; anesthesia induction; article; comparative effectiveness; controlled study; dizziness; double blind procedure; drug efficacy; drug induced headache; drug safety; female; human; major clinical study; male; muscle cramp; myalgia; postoperative nausea and vomiting; priority journal; prospective study; randomized controlled trial; thyroidectomy; visual analog scale
DOI:
10.4103/1658-354X.109817
