Περίληψη:
Background/aim: In light of the controversial published literature, this study aims to examine the potential prognostic role of AR immunohistochemical expression in triple negative breast cancer (TNBC). Patients and methods: Ninety patients with TNBC were included in this study; the associations between AR expression (Allred score), clinicopathological variables (stage, grade, histological subtype, tumor size, nodal status, age at diagnosis, Ki67 expression, and p53 expression), and overall survival were evaluated. Results: AR expression was not associated with stage, grade, histological subtype, tumor size, nodal status, age at diagnosis, Ki67 expression, and p53 expression. AR immunopositivity was not associated with overall survival either at the univariate or at the multivariate Cox regression analysis (multivariate hazard ratio =0.66, 95% confidence interval: 0.26–1.70, P=0.393). Conclusion: AR expression does not seem to play a prognostic role in TNBC. © 2015 Giannos et al.
Συγγραφείς:
Giannos, A.
Filipits, M.
Zagouri, F.
Brandstetter, A.
Tsigginou, A.
Sotiropoulou, M.
Papaspyrou, I.
Sergentanis, T.N.
Psaltopoulou, T.
Rodolakis, A.
Antsaklis, A.
Dimopoulos, M.-A.
Dimitrakakis, C.
Λέξεις-κλειδιά:
androgen receptor; Ki 67 antigen; protein p53, adult; age; antigen expression; Article; cancer classification; cancer grading; cancer prognosis; cancer staging; disease association; female; histopathology; human; human tissue; immunohistochemistry; major clinical study; overall survival; prognostic assessment; protein expression; triple negative breast cancer; tumor volume
