Τίτλος:
Risk of heart failure and death after prolonged smoking cessation: Role of amount and duration of prior smoking
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background-According to the 2004 Surgeon General's Report on Health Consequences of Smoking, after >15 years of abstinence, the cardiovascular risk of former smokers becomes similar to that of never-smokers. Whether this health benefit of smoking cessation varies by amount and duration of prior smoking remains unclear. Methods and Results-Of the 4482 adults ≥65 years without prevalent heart failure (HF) in the Cardiovascular Health Study, 2556 were never-smokers, 629 current smokers, and 1297 former smokers with >15 years of cessation, of whom 312 were heavy smokers (highest quartile; ≥32 pack-years). Age-sex-race-Adjusted hazard ratios (aHR) and 95% confidence intervals (CI) for centrally adjudicated incident HF and mortality during 13 years of follow-up were estimated using Cox regression models. Compared with never-smokers, former smokers as a group had similar risk for incident HF (aHR, 0.99; 95% CI, 0.85-1.16) and all-cause mortality (aHR, 1.08; 95% CI, 0.96-1.20), but former heavy smokers had higher risk for both HF (aHR, 1.45; 95% CI, 1.15-1.83) and mortality (aHR, 1.38; 95% CI, 1.17-1.64). However, when compared with current smokers, former heavy smokers had lower risk of death (aHR, 0.64; 95% CI, 0.53-0.77), but not of HF (aHR, 0.97; 95% CI, 0.74-1.28). Conclusions-After >15 years of smoking cessation, the risk of HF and death for most former smokers becomes similar to that of never-smokers. Although this benefit of smoking cessation is not extended to those with ≥32 packyears of prior smoking, they have lower risk of death relative to current smokers. © 2015 American Heart Association, Inc.
Συγγραφείς:
Ahmed, A.A.
Patel, K.
Nyaku, M.A.
Kheirbek, R.E.
Bittner, V.
Fonarow, G.C.
Filippatos, G.S.
Morgan, C.J.
Aban, I.B.
Mujib, M.
Desai, R.V.
Allman, R.M.
White, M.
Deedwania, P.
Howard, G.
Bonow, R.O.
Fletcher, R.D.
Aronow, W.S.
Ahmed, A.
Περιοδικό:
Circulation: Heart Failure
Εκδότης:
Lippincott Williams and Wilkins
Λέξεις-κλειδιά:
acute heart infarction; adult; cardiovascular mortality; cardiovascular risk; Conference Paper; controlled study; disease association; female; follow up; heart death; heart failure; human; human experiment; incidence; male; normal human; peripheral occlusive artery disease; prevalence; priority journal; smoking; smoking cessation; adverse effects; aged; chi square distribution; clinical trial; comparative study; epidemiology; heart failure; mortality; multicenter study; multivariate analysis; prevention and control; prognosis; proportional hazards model; prospective study; risk assessment; risk factor; time; United States; very elderly, Aged; Aged, 80 and over; Chi-Square Distribution; Female; Heart Failure; Humans; Incidence; Male; Multivariate Analysis; Prognosis; Proportional Hazards Models; Prospective Studies; Risk Assessment; Risk Factors; Smoking; Smoking Cessation; Time Factors; United States
DOI:
10.1161/CIRCHEARTFAILURE.114.001885
